Generated by All in One SEO v5.0.0.1, this is an llms.txt file, used by LLMs to index the site. # Pascoal Lab University of Pittsburgh ## Sitemaps - [XML Sitemap](https://pascoallab.org/sitemap.xml): Contains all public & indexable URLs for this website. ## Posts - [Brain Cell Biomarker for Preclinical Alzheimer Disease Identified](https://pascoallab.org/brain-cell-biomarker-for-preclinical-alzheimer-disease-identified/) - Astrocytes, cells that are involved in the brain’s support system, might play an important role in the progression of Alzheimer disease, according to results from 1016 participants with and without amyloid-β pathology who were all cognitively unimpaired. Participants were aged 70 years on average. Amyloid-β accumulation was linked with an increase in tau tangles only in the - [Is Inflammation In The Brain Causing Alzheimer’s Disease?](https://pascoallab.org/is-inflammation-in-the-brain-causing-alzheimers-disease/) - The brain of a person with Alzheimer’s disease has a few hallmark traits. First, a buildup of plaques made of proteins called amyloid beta. Second, are tangles of another protein, called tau, within individual neurons. A third major indicator is inflammation. While researchers have long thought brain inflammation was a byproduct of the disease itself, there’s - [Pitt Psychiatry Research Published in Alzheimer's & Dementia](https://pascoallab.org/pitt-psychiatry-research-published-in-alzheimers-dementia/) - Pitt Psychiatry investigators have recently published studies in Alzheimer's & Dementia. Below is a summary of recent original research on neural factors underlying cognitive and depressive symptoms in late life, sleep and rest–activity rhythms across different cognitive aging pathways, and the association between attention-deficit/hyperactivity disorder and Alzheimer’s disease. Altered Triple Network Model Connectivity Is Associated with - [Three Psychiatry Postdoctoral Research Trainees Receive University of Pittsburgh Postdoctoral Association Awards](https://pascoallab.org/three-psychiatry-postdoctoral-research-trainees-receive-university-of-pittsburgh-postdoctoral-association-awards/) - Congratulations to Ligia Antezana, PhD; Carolina Soares, PhD; and Lindsay Taraban, PhD, who received Best Poster Presentation Awards at the University of Pittsburgh Postdoctoral Association 2025 Postdoctoral Data & Dine Symposium. Dr. Antezana, Dr. Soares, and Dr. Taraban were counted among 11 total award recipients selected from 130 submissions. Dr. Antezana is a clinical psychologist who conducts research in the lab - [19 people were honored at Pitt’s Postdoctoral Research Symposium](https://pascoallab.org/19-people-were-honored-at-pitts-postdoctoral-research-symposium/) - On April 14, the University of Pittsburgh held its 18th annual Postdoctoral Research Symposium, hosted by the Office of Academic Career Development for the schools of the health sciences. Postdocs presented 115 posters at the event, and 11 of them took home $500 awards in recognition of the best poster presentations. The winners were: Amandine - [Investing in Hope](https://pascoallab.org/investing-in-hope/) - One day a week, when he’s not conducting research on Alzheimer’s disease in his Oakland lab, Dr. Tharick Pascoal treats patients at the memory clinic at UPMC. Sometimes what he observes is startling – a man who was fairly coherent six months ago staring back at him blankly, lost in the fog of the dreaded - [Pitt study could open opportunity for earlier Alzheimer's detection](https://pascoallab.org/pitt-study-could-open-opportunity-for-earlier-alzheimers-detection/) - PITTSBURGH (KDKA) -- A study by the University of Pittsburgh claims to have found an earlier detection for people who may have Alzheimer's, and it used a test many of us routinely take. Blood tests were used to see if someone could develop the disease or not. Doctors said this could revolutionize how we - [New Blood Biomarker Can Predict if Cognitively Healthy Elderly Will Develop Alzheimer’s Disease](https://pascoallab.org/new-blood-biomarker-can-predict-if-cognitively-healthy-elderly-will-develop-alzheimers-disease/) - PITTSBURGH — Why do some people develop Alzheimer’s disease while others don’t? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates — a telltale sign of Alzheimer’s brain pathology — never go on to develop Alzheimer’s-associated dementias? University of Pittsburgh School of Medicine researchers appear to have found the answer. - [VJ Dementia with Marina S. Medeiros](https://pascoallab.org/vj-dementia-with-marina-s-medeiros/) - Link: https://www.vjdementia.com/speaker/marina-scop-medeiros/ - [Blood testing for Alzheimer’s could be game changer in early diagnosis](https://pascoallab.org/blood-testing-for-alzheimers-could-be-game-changer-in-early-diagnosis/) - Seven million Americans are living with Alzheimer’s disease. One in three people over the age of 85 deal with it. Early detection is key, so that people can start treatment. But unfortunately, diagnosis can involve expensive procedures like a PET scan or a spinal tap. Researchers say blood testing could be a simple, cost-effective way - [UPMC recruiting participants for research study involving blood tests, early Alzheimer’s detection](https://pascoallab.org/upmc-recruiting-participants-for-research-study-involving-blood-tests-early-alzheimers-detection/) - PITTSBURGH — Research in Sweden shows that when blood tests are quantified in primary care settings, they are more than 90 accurate in identifying the presence of pathological proteins in the brain that are associated with Alzheimer’s Disease, according to a new study revealed at the 2024 Alzheimer’s Association International Conference in July. Now, UPMC - [Pittsburgh is at the forefront of research for warning signs of Alzheimer's disease](https://pascoallab.org/walk-to-end-alzheimers-tpl/) - Link: https://www.cbsnews.com/pittsburgh/video/pittsburgh-is-at-the-forefront-of-research-for-warning-signs-of-alzheimers-disease - [The HEAD Study - Pascoal Laboratory, University of Pittsburgh](https://pascoallab.org/the-head-study-pascoal-laboratory-university-of-pittsburgh/) - Researchers around the world are collaborating in the largest head-to-head tau PET dataset and harmonization effort ever undertaken. The findings could lead to significant advances in the diagnosis and treatment of Alzheimer's Disease. Drs. Tharick Pascoal (University of Pittsburgh) and Suzanne Baker (Lawrence Berkeley National Laboratory) conceptualized The HEAD Study in late 2020 under the - [New research could be game-changer for early detection of Alzheimer's Disease](https://pascoallab.org/new-research-could-be-game-changer-for-early-detection-of-alzheimers-disease/) - The Alzheimer's Association says the disease is a growing public health crisis in PA. Major steps are being taken here in Allegheny County, whether it's addressing under-represented communities, or helping with early detection. Link: https://www.cbsnews.com/pittsburgh/video/new-research-could-be-game-changer-for-early-detection-of-alzheimers-disease/ - [Pitt Psychiatry’s 2024 Research Day, Part II: 173 Poster Presentations!](https://pascoallab.org/pitt-psychiatrys-2024-research-day-part-ii-173-poster-presentations/) - Pitt Psychiatry’s 2024 Research Day featured 173 poster presentations from faculty, trainees, and staff. Each poster presenter was visited by one pair of reviewers from among a total of 55 faculty discussants. During the plenary session, Outstanding Poster Presentation Awards were presented to the following recipients: Douglas Teixeira Leffa, MD, PhD Link: https://psychiatry.pitt.edu/pitt-psychiatrys-2024-research-day-part-ii-173-poster-presentations - [News about Dr. Pascoal's participation in WTD](https://pascoallab.org/news-about-dr-pascoals-participation-in-wtd/) - El neurólogo brasileño afincado en Pensilvania Tharick Pascoal es uno de los ochenta peregrinos que, procedentes de 26 países diferentes, participan desde este lunes en la segunda edición de Walking the Talk for Dementia. Una iniciativa que define como “un evento muy especial por el contacto con los pacientes, con los cuidadores, que te aportan una visión muy - [New Research from Pitt Psychiatry on Alzheimer’s Disease Biomarkers](https://pascoallab.org/new-research-from-pitt-psychiatry-on-alzheimers-disease-biomarkers/) - Department of Psychiatry investigators focused on Alzheimer’s Research—Victor Villemagne, MD (Professor of Psychiatry); Tharick Pascoal, MD, PhD (Associate Professor of Psychiatry and Neurology); and Thomas Karikari, PhD (Assistant Professor of Psychiatry)—have recently published studies improving our understanding of biomarkers for Alzheimer’s disease. Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease (senior - [Two Psychiatry Postdoctoral Research Trainees Receive University of Pittsburgh Postdoctoral Association Awards](https://pascoallab.org/two-psychiatry-postdoctoral-research-trainees-receive-university-of-pittsburgh-postdoctoral-association-awards/) - Congratulations to Cynthia Felix, MD, MPH, and Shalini Sivathasan, PhD, who received Best Poster Presentation Awards at the University of Pittsburgh Postdoctoral Association 2024 Postdoctoral Data & Dine Symposium. Dr. Felix is a postdoctoral associate focusing on advanced Alzheimer’s disease biomarkers in the lab of Tharick Pascoal, MD, PhD (Associate Professor of Psychiatry and Neurology). Her award-winning - [Microglia Conflicted: To Help, or to Hinder, Tau’s March Across the Brain?](https://pascoallab.org/microglia-conflicted-to-help-or-to-hinder-taus-march-across-the-brain/) - Do microglia thwart neurodegenerative disease, or help it along? Do they keep amyloid in check with one hand, while goading tau entanglement with the other? Do they protect neurons early on in disease, but sour into synaptic slayers later? As the field gears up to target these reactive immune cells in clinical trials (see Part 8 of - [In Amyloid Cascade, Do Reactive Astrocytes Bridge Plaques and Tangles?](https://pascoallab.org/in-amyloid-cascade-do-reactive-astrocytes-bridge-plaques-and-tangles/) - Why do some people with amyloid plaques decline, while others do not? In the May 29 Nature Medicine, researchers led by Tharick Pascoal at the University of Pittsburgh laid some of the blame on reactive astrocytes. Among cognitively healthy people with amyloid plaques, only those whose astrocytes were activated, as judged by plasma GFAP, accumulated - [Over the Span of AD, Roles of Astrocytes and Microglia Change](https://pascoallab.org/over-the-span-of-ad-roles-of-astrocytes-and-microglia-change/) - As neuronal supporters and immune surveyors, astrocytes and microglia are no mere bystanders to the neuronal mayhem that unfolds in Alzheimer’s disease. At the AD/PD meeting, held March 5-9 in Lisbon, scientists presented new twists on the relative contributions of the two cell types to various aspects of AD, including plaque and tangle accumulation, synaptic - [Brain Inflammation May Trigger Alzheimer's-Linked Anger, Anxiety](https://pascoallab.org/brain-inflammation-may-trigger-alzheimers-linked-anger-anxiety/) - Alzheimer’s patients are notoriously irritable, agitated and anxious – and researchers now think they know why. Brain inflammation appears to influence the mood problems of Alzheimer’s patients, rather than traditional markers of the disease like amyloid beta or tau proteins, researchers report in the Nov. 27 issue of the journal JAMA Network Open. Brain inflammation - [Irritability, Agitation and Anxiety in Alzheimer’s Patients Caused by Brain Inflammation, Pitt Study Says](https://pascoallab.org/irritability-agitation-and-anxiety-in-alzheimers-patients-caused-by-brain-inflammation-pitt-study-says/) - Common neuropsychiatric symptoms that doctors see in Alzheimer’s disease patients originate from brain inflammation rather than amyloid and tau proteins, report University of Pittsburgh School of Medicine researchers today in JAMA Network Open. The finding strengthens mounting evidence for the role of neuroinflammation in Alzheimer’s progression and suggests new pathways for the development of therapies - [Alzheimer's & Dementia and Nature Aging: New Alzheimer's Disease Research](https://pascoallab.org/alzheimers-dementia-and-nature-aging-new-alzheimers-disease-research/) - The Pascoal Lab (PI: Tharick Pascoal, MD, PhD; Associate Professor of Psychiatry and Neurology) and colleagues have published recent research findings in Alzheimer's & Dementia and Nature Aging examining biomarkers and pathophysiological progression of Alzheimer's disease. “These two publications contribute to our understanding of the biomarkers and pathophysiological processes associated with the progression of tau pathology in Alzheimer's disease, which is closely - [Advancing Against Alzheimer’s](https://pascoallab.org/advancing-against-alzheimers/) - Two older adults check in at the hospital to undergo brain scans. Their results are remarkably similar. Both show an accumulation of amyloid plaques—proteins that clog the spaces between neurons and serve as a telltale sign of Alzheimer’s disease. But, as time passes, only one of the patients experiences a steep cognitive decline. The other patient - [Finding a Biomarker for Alzheimer's Disease](https://pascoallab.org/finding-a-biomarker-for-alzheimers-disease/) - In this UPMC Physician Journal feature, meet Tharick Pascoal, MD, PhD, neurologist and associate professor of Neurology and Psychiatry at the University of Pittsburgh School of Medicine, as he and his team conduct research to find a biomarker based on tau proteins in the brain, which may help clinicians provide an earlier and more accurate diagnosis - [Exploring a Connection Between ADHD and Alzheimer’s](https://pascoallab.org/exploring-a-connection-between-adhd-and-alzheimers/) - New research has shed light on the connection between attention deficit-hyperactivity disorder (ADHD) and Alzheimer’s, two neurological conditions that manifest in very different ways. One study showed that people who are genetically predisposed to ADHD may be more likely to develop cognitive decline and Alzheimer’s disease later in life. Although this connection has been suspected - [Best Life: Researchers link ADHD, alzheimers](https://pascoallab.org/best-life-researchers-link-adhd-alzheimers/) - More than 6.5 million people are living with Alzheimer’s in the United States. More than six million children have attention-deficit/hyperactivity disorder or ADHD. One is usually diagnosed later in life, and the other is diagnosed earlier, but could the two actually be linked? The answer could help save minds and memories. Different generations, different diagnoses, - [New Alzheimer’s blood test may determine who is at risk of dementia: 'Could be game changer'](https://pascoallab.org/new-alzheimers-blood-test-may-determine-who-is-at-risk-of-dementia-could-be-game-changer/) - A blood test may help identify individuals at risk for Alzheimer’s before they show any signs of the disease, according to a new study published in the journal Nature Medicine. The blood test looks at the activity of star-shaped brain cells in the blood called astrocytes, according to researchers from the University of Pittsburgh School of Medicine. Only - [Microglial and Astrocyte Reactivity Are Key to Determining Alzheimer’s Disease Progression](https://pascoallab.org/microglial-and-astrocyte-reactivity-are-key-to-determining-alzheimers-disease-progression/) - Tharick Pascoal, MD, PhD (Associate Professor of Psychiatry) is an internationally recognized expert on the imaging and fluid biomarkers of Alzheimer’s disease and related dementias. He recently published two papers examining the multifaceted but interactive nature of Alzheimer’s disease pathology. “Microglia and astrocytes are glial cells that act together and play a major role in the - [Prick of the bunch: Blood test can predict who'll develop Alzheimer's disease, 'game-changing' study suggests](https://pascoallab.org/prick-of-the-bunch-blood-test-can-predict-wholl-develop-alzheimers-disease-game-changing-study-suggests/) - Scientists may have found the true cause of Alzheimer's disease — and believe the condition can be detected using a simple blood test. Experts have long known the build-up of amyloid in the brain is linked to the disease, but whether the plaques are a cause or a symptom has remained a mystery. Even more puzzling is - [Alzheimer’s blood test edges closer as key brain cell identified](https://pascoallab.org/alzheimers-blood-test-edges-closer-as-key-brain-cell-identified/) - A blood test that can detect people at early risk of Alzheimer’s is a step closer after scientists implicated a key brain cell in the development of the disease. As well as providing the basis for a test, their work points to a resolution of one of the persistent mysteries of the condition — why - [University of Pittsburgh School of Medicine Promotes Tharick Pascoal, MD, PhD, to Associate Professor of Psychiatry](https://pascoallab.org/university-of-pittsburgh-school-of-medicine-promotes-tharick-pascoal-md-phd-to-associate-professor-of-psychiatry/) - We are delighted to announce that Tharick Pascoal, MD, PhD, has been promoted to Associate Professor of Psychiatry by the University of Pittsburgh School of Medicine. Dr. Pascoal received his MD from Federal University of Pelotas in Brazil. He completed his residency training in neurology at Pontifical Catholic University of Rio Grande do Sul. Dr. Pascoal then - [Pitt Psychiatry Investigators Report New Findings in Alzheimer’s Disease and Dementia & Late-Life Depression Research](https://pascoallab.org/pitt-psychiatry-investigators-report-new-findings-in-alzheimers-disease-and-dementia-late-life-depression-research/) - Acta Neuropathologica: Plasma P-Tau231, A New Biomarker for Incipient Alzheimer's Disease Pathology Scientists including Tharick Pascoal, MD, PhD (Assistant Professor of Psychiatry and Neurology) from Pitt Psychiatry have published the discovery and validation of a new blood biomarker of Alzheimer’s disease which, for the first time, can produce remarkably early detection of the pathology. The quantification of phosphor-tau231 - [Nature Medicine: Microglial Activation Is Involved in the Spread of Tau Tangles in Alzheimer’s Disease](https://pascoallab.org/nature-medicine-microglial-activation-is-involved-in-the-spread-of-tau-tangles-in-alzheimers-disease/) - Investigators including Pitt Psychiatry’s Tharick Pascoal, MD, PhD (Assistant Professor of Psychiatry and Neurology), have published a paper in Nature Medicine investigating the correlation between microglial activation, abnormal tau tangles (a pattern known as Braak stages), and dementia symptoms. Recent research has suggested that microglial activation is a key player in the progression of tau pathology, which can lead - [Modeling Associations Between Pathological Pathways in the Progression of Alzheimer’s Disease Using PET Imaging](https://pascoallab.org/news-at-university-of-pittsburgh-website-highlights-a-recent-article-published-by-our-researcher-2/) - Dr. Tharick Pascoal is a clinical neurologist and a post-doctoral fellow at Douglas Hospital, McGill University in Montreal, Canada. Through his research, he aims to develop therapeutic targets for neurodegenerative diseases through the identification of biomarkers of pathological processes in the human brain. He employs brain-imaging techniques in this endeavor, including positron emission tomography (PET) - [Cutting-edge Research in Alzheimer’s Disease Biomarkers: Introducing Victor Villemagne and Tharick Pascoal](https://pascoallab.org/cutting-edge-research-in-alzheimers-disease-biomarkers-introducing-victor-villemagne-md-and-tharick-pascoal-md-phd/) - We are pleased to announce that Victor Villemagne, MD, has joined the faculty as Professor of Psychiatry, and Tharick Pascoal, MD, PhD, has been appointed Assistant Professor of Psychiatry. Dr. Villemagne and Dr. Pascoal are widely recognized experts in Alzheimer’s disease biomarkers and will greatly enhance our innovative research program in this area. Dr. Villemagne brings to Pitt - [Pitt Psychiatry Hosts a Tremendous Research “Half” Day](https://pascoallab.org/pitt-psychiatry-hosts-a-tremendous-research-half-day/) - On June 9, 2021, the Department of Psychiatry held its 2nd virtual Research Day, featuring presentations on health equity research, a speed dat(a)ing session, a keynote address, and honors and awards. The event was billed as a Research “Half” Day, as we hope and expect for the second half of the event, a poster session, - [Brain Tissue Inflammation Drives Alzheimer’s Disease](https://pascoallab.org/brain-tissue-inflammation-drives-alzheimers-disease/) - PITTSBURGH – Neuroinflammation is the key driver of the spread of pathologically misfolded proteins in the brain and causes cognitive impairment in patients with Alzheimer’s disease, researchers from the University of Pittsburgh School of Medicine reveal in a paper published today in Nature Medicine. For the first time ever, the researchers showed in living patients that neuroinflammation—or activation of - [Pitt Psychiatry Faculty Members Invited to Contribute to World Alzheimer Report ](https://pascoallab.org/pitt-psychiatry-faculty-members-invited-to-contribute-to-world-alzheimer-report/) - In fall 2021, Alzheimer’s Disease International published World Alzheimer Report 2021: Journey though the diagnosis of dementia, a compendium of research on the disease, currently the seventh leading cause of mortality worldwide. The report addresses numerous challenges and complexities—including the prevalence of myths and misinformation—that inhibit effective diagnosis and treatment Alzheimer’s disease. Pitt Psychiatry is home - [Molecular Psychiatry: Astrocyte Biomarker Signatures of Amyloid-β and Tau Pathologies in Alzheimer’s Disease](https://pascoallab.org/molecular-psychiatry-astrocyte-biomarker-signatures-of-amyloid-β-and-tau-pathologies-in-alzheimers-disease/) - In Alzheimer’s disease, reactive astrocytes can play an important role in the pathophysiology of the disease. Amyloid-β and tau tangles—the two main pathological hallmarks of Alzheimer’s disease—are associated with astrocyte reactivity. However, knowledge about amyloid-β- and tau-specific contributions to reactive astrocyte biomarkers in patients with Alzheimer’s disease is limited. To improve our understanding of the - [Study Challenges Dogma Behind Alzheimer’s Disease Drug Trials](https://pascoallab.org/study-challenges-dogma-behind-alzheimers-disease-drug-trials/) - PITTSBURGH - Contrary to early studies, brain levels of enzymes that regulate DNA-folding drop as Alzheimer’s disease progresses, neuroscientists from the University of Pittsburgh, McGill University and Harvard University reported today in Nature Communications. These dogma-challenging findings, verified across two independent cohorts of live patients with Alzheimer’s disease and on post-mortem brain tissues, show that reduced levels of Histone Deacetylase I (HDAC - [Pitt Psychiatry Awarded $33.5M NIH Program Project Grant Focused on the Pathological and Clinical Progression of AD](https://pascoallab.org/pitt-psychiatry-awarded-33-5m-nih-program-project-grant-focused-on-the-pathological-and-clinical-progression-of-alzheimers-disease/) - The National Institute on Aging (NIA) has awarded the University of Pittsburgh Department of Psychiatry a Program Project Grant (PPG) renewal for “The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's disease.” The Alzheimer’s PPG will be led by a multiple principal investigator team including Ann Cohen, PhD (Associate Professor of Psychiatry), Howard - [Transcranial Direct Current Stimulation vs Sham for the Treatment of Inattention in Adults](https://pascoallab.org/transcranial-direct-current-stimulation-vs-sham-for-the-treatment-of-inattention-in-adults/) - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition that affects 2.5% of adults worldwide. Pharmacotherapy is the recommended initial treatment for most adults, but patient adherence can be low due to adverse effects and other concerns. Therefore, the investigation of nonpharmaceutical treatments for ADHD is critical. One option is transcranial direct current stimulation, a noninvasive technique - [Genetic risk of ADHD may boost odds of Alzheimer's in old age](https://pascoallab.org/genetic-risk-of-adhd-may-boost-odds-of-alzheimers-in-old-age/) - Having a genetic predisposition to attention-deficit/hyperactivity disorder, or ADHD, is associated with cognitive decline and may predict Alzheimer's disease in old age, early research released Thursday suggests. Recent large studies have hinted at a link between ADHD and Alzheimer's, the researchers said a news release, but this is the first study to tie genetic risk ## Pages - [Home](https://pascoallab.org/) - Our lab is interested in the quantification of brain pathophysiology in patients with Alzheimer’s disease (AD) and related dementias. - [Team](https://pascoallab.org/team/) - [et_pb_section fb_built=”1″ _builder_version=”4.21.0″ _module_preset=”default” background_color=”#edeef3″ use_background_color_gradient=”off” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”43px||70px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.21.0″ _module_preset=”default” background_enable_color=”off” max_width=”1200px” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” header_2_font_size_tablet=”” header_2_font_size_phone=”26px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]Principal Investigator[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row column_structure=”3_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” custom_padding_last_edited=”on|phone” admin_label=”Cristiano Aguzzoli” module_class=”reverse” _builder_version=”4.21.0″ background_color=”#FFFFFF” max_width=”1200px” module_alignment=”center” min_height=”300px” custom_margin=”||||false|false” custom_margin_tablet=”||||false|false” custom_margin_phone=”||0px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|true” custom_padding_tablet=”0px||0px||true|true” custom_padding_phone=”||||true|true” animation_style=”fade” border_color_all=”#1c2430″ box_shadow_style=”preset1″ box_shadow_vertical=”5px” - [Studies](https://pascoallab.org/studies/) - [et_pb_section fb_built=”1″ custom_padding_last_edited=”off|desktop” admin_label=”Services Section” _builder_version=”4.21.0″ background_color=”#EDEEF3″ use_background_color_gradient=”off” custom_margin=”|||” custom_margin_tablet=”0px|0px|0px|0px|true|true” custom_margin_last_edited=”off|desktop” custom_padding=”70px|0px|70px|0px|false|false” custom_padding_tablet=”|||0px” bottom_divider_height=”80%” bottom_divider_repeat=”0.4x” animation_direction=”bottom” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row make_equal=”on” custom_padding_last_edited=”on|phone” admin_label=”Service Area” _builder_version=”4.21.0″ background_color=”#FFFFFF” max_width=”1200px” module_alignment=”center” custom_margin=”0px||70px||false|false” custom_padding=”25px|25px|25px|25px|true|true” custom_padding_tablet=”” custom_padding_phone=”30px|30px|30px|30px|true|true” animation_style=”fade” box_shadow_style=”preset1″ box_shadow_vertical=”5px” box_shadow_spread=”-7px” use_custom_width=”on” custom_width_px=”1440px” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ custom_padding=”|||” custom_css_main_element=”margin: auto;” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_font=”Roboto Slab|300|||||||” text_font_size=”16px” header_3_text_align=”left” text_orientation=”justified” custom_margin=”0px||0px||false|false” - [Gallery](https://pascoallab.org/gallery/) - [et_pb_section fb_built=”1″ admin_label=”Gallery Section” _builder_version=”4.27.2″ background_enable_color=”off” background_color_gradient_stops=”#ffffff 0%|rgba(255,255,255,0) 100%” custom_margin=”0px||0px||false|false” custom_padding=”43px||43px||true|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” max_width=”1200px” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” header_2_font_size_tablet=”” header_2_font_size_phone=”26px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”]Lab Life[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” max_width=”1200px” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][wdcl_image_carousel animation_speed=”1000ms” autoplay_speed=”5000ms” arrow_color=”#EDEEF3″ arrow_bg=”#1C2430″ use_lightbox=”on” _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″][wdcl_image_carousel_child photo=”https://pascoallab.org/wp-content/uploads/2025/04/lif.png” _builder_version=”4.27.4″ _module_preset=”default” - [Contact](https://pascoallab.org/contact/) - [et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” admin_label=”Contact Section” _builder_version=”4.21.0″ background_color=”#edeef3″ background_color_gradient_stops=”#ffffff 0%|rgba(255,255,255,0) 100%” custom_padding=”43px||70px||false|false” custom_padding_tablet=”60px||120px||false|false” custom_padding_phone=”0px||120px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_2,1_2″ admin_label=”Contact Area” _builder_version=”4.27.0″ max_width=”1200px” custom_margin=”|auto|43px|auto|false|false” custom_padding=”|||” animation_style=”fade” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” make_equal=”on” sticky_enabled=”0″][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_cta title=”Lab Adress” button_url=”#” _builder_version=”4.27.0″ header_level=”h4″ header_font=”Roboto Slab|600|||||||” header_line_height=”1.8em” body_font=”||||||||” body_line_height=”1.8em” background_color=”rgba(0,0,0,0)” custom_button=”on” button_text_size=”14px” button_text_color=”#0072ff” button_border_width=”0px” button_letter_spacing=”4px” button_font=”Bungee||||||||” button_use_icon=”off” background_layout=”light” custom_padding=”40px|30px|40px|30px|true|true” hover_enabled=”0″ - [News](https://pascoallab.org/news/) - [et_pb_section fb_built=”1″ admin_label=”Blog Section” _builder_version=”4.20.4″ background_enable_color=”off” background_color_gradient_stops=”#ffffff 0%|rgba(255,255,255,0) 99%” custom_padding=”60px||120px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row use_custom_gutter=”on” gutter_width=”2″ admin_label=”Blog Area” _builder_version=”4.19.2″ width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” height_tablet=”” height_phone=”” height_last_edited=”on|phone” animation_style=”fade” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_blog fullwidth=”off” posts_number=”200″ include_categories=”10″ show_author=”off” show_categories=”off” module_class=”pa-blog-equal-height” _builder_version=”4.27.0″ header_font=”Roboto Slab|500|||||||” header_line_height=”1.8em” body_font=”Roboto Slab|300|||||||” body_font_size=”16px” body_line_height=”1.8em” meta_font=”Roboto Slab||||||||” pagination_font=”Bungee||||||||” pagination_text_color=”#0072ff” animation_style=”fade” hover_enabled=”0″ - [Publications](https://pascoallab.org/all-publications/) - [et_pb_section fb_built=”1″ admin_label=”Blog Section” module_id=”results” _builder_version=”4.21.0″ background_color=”#EDEEF3″ use_background_color_gradient=”off” custom_margin=”0px||0px||false|false” custom_padding=”43px||43px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row disabled_on=”on|off|off” _builder_version=”4.21.0″ _module_preset=”default” max_width=”1200px” custom_margin=”||||false|false” custom_padding=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” custom_padding=”|0px|||false|false” custom_css_main_element=”display: flex;||justify-content: space-between;” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_url=”#results” button_text=”Inflammation” module_class=”article-tag” _builder_version=”4.21.0″ _module_preset=”default” custom_button=”on” button_text_color=”#EDEEF3″ button_bg_color=”#1C2430″ button_border_width=”0px” button_border_radius=”40px” button_font=”Roboto Slab||||||||” button_use_icon=”off” custom_margin=”||0px||false|false” custom_padding=”||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][/et_pb_button][et_pb_button button_url=”#results” button_text=”Tau PET” module_class=”article-tag” _builder_version=”4.21.0″ _module_preset=”default” custom_button=”on” button_text_color=”#EDEEF3″ button_bg_color=”#1C2430″ - [Team Test](https://pascoallab.org/team-test/) - [et_pb_section fb_built=”1″ _builder_version=”4.21.0″ _module_preset=”default” background_color=”#edeef3″ use_background_color_gradient=”off” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”43px||70px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.21.0″ _module_preset=”default” background_enable_color=”off” max_width=”1200px” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]Principal Investigator[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row column_structure=”3_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” custom_padding_last_edited=”on|phone” admin_label=”Cristiano Aguzzoli” module_class=”reverse” _builder_version=”4.21.0″ background_color=”#FFFFFF” max_width=”1200px” module_alignment=”center” custom_margin=”||||false|false” custom_margin_tablet=”||||false|false” custom_margin_phone=”||0px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|true” custom_padding_tablet=”0px||0px||true|true” custom_padding_phone=”||||true|true” animation_style=”fade” hover_enabled=”0″ border_color_all=”#1c2430″ box_shadow_style=”preset1″ box_shadow_vertical=”5px” box_shadow_spread=”-7px” global_colors_info=”{}” custom_margin__hover_enabled=”off|desktop” - [Research](https://pascoallab.org/research/) - [et_pb_section fb_built=”1″ custom_padding_last_edited=”off|desktop” next_background_color=”#ffffff” admin_label=”Services Section” _builder_version=”4.20.4″ background_color=”#FFFFFF” background_color_gradient_direction=”0deg” background_color_gradient_stops=”#ffffff 0%|rgba(255,255,255,0) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#ffffff” background_color_gradient_end=”rgba(255,255,255,0)” custom_margin=”|||” custom_margin_tablet=”0px|0px|0px|0px|true|true” custom_margin_last_edited=”off|desktop” custom_padding=”64px|0px|64px|0px|false|false” custom_padding_tablet=”|||0px” bottom_divider_style=”asymmetric3″ bottom_divider_height=”80%” bottom_divider_repeat=”0.4x” animation_direction=”bottom” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row custom_padding_last_edited=”on|phone” admin_label=”Service Area” _builder_version=”4.20.4″ background_color=”#ffffff” custom_margin=”||30px||false|false” custom_padding=”26px|60px|20px|60px|false|true” custom_padding_tablet=”” custom_padding_phone=”30px|30px|30px|30px|true|true” box_shadow_style=”preset3″ box_shadow_vertical=”80px” box_shadow_blur=”200px” box_shadow_spread=”-40px” use_custom_width=”on” custom_width_px=”1440px” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text admin_label=”Title” _builder_version=”4.20.4″ text_font=”||||||||” header_font=”||||||||” header_2_font=”Roboto - [Principal Investigator](https://pascoallab.org/pi/) - [et_pb_section fb_built=”1″ bg_img_1=”https://ideasci.zimmer-lab.org/wp-content/uploads/2022/09/political-candidate-25.png” background_size_1=”initial” background_repeat_1=”no-repeat” background_position_1=”top_right” disabled_on=”on|off|off” admin_label=”Header” _builder_version=”4.20.4″ background_color=”RGBA(255,255,255,0)” background_color_gradient_stops=”#ffffff 0%|rgba(255,255,255,0) 100%” custom_margin=”60px||0px||false|false” custom_padding=”0px||0px||true” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” padding_top_bottom_link_2=”false” padding_left_right_link_2=”false” _builder_version=”4.20.4″ width=”100%” max_width=”70%” min_height=”359px” height=”413px” max_height=”1000px” custom_margin=”0px||||false|false” custom_padding=”0px||0px||true” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}” width__hover_enabled=”on|desktop” max_width__hover_enabled=”on|desktop” width__hover=”100%” max_width__hover=”70%” height__hover_enabled=”on|desktop” max_height__hover_enabled=”on|desktop” min_height__hover_enabled=”on|desktop” height__hover=”413px” max_height__hover=”1000px” min_height__hover=”359px” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.19.2″ background_image=”https://ideasci.zimmer-lab.org/wp-content/uploads/2022/12/Tharick_Pascoal.jpeg” background_size=”contain” z_index=”999″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.2″ - [Alumni](https://pascoallab.org/alumni/) - [et_pb_section fb_built=”1″ _builder_version=”4.20.4″ _module_preset=”default” custom_padding=”64px||64px||false|false” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” background_color=”#FFFFFF” background_color_gradient_stops=”#ffffff 0%|rgba(255,255,255,0) 100%” sticky_enabled=”0″][et_pb_row column_structure=”3_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.20.4″ background_color=”#ffffff” min_height=”380.5px” custom_margin=”30px||||false|false” custom_padding=”0px||0px|||” animation_style=”fade” hover_enabled=”0″ border_radii=”on|20px|20px|20px|20px” border_color_all=”#efac25″ border_width_top=”11px” box_shadow_style=”preset3″ box_shadow_vertical=”17px” box_shadow_blur=”41px” box_shadow_color=”rgba(175,196,204,0.18)” global_colors_info=”{}” custom_margin__hover_enabled=”on|desktop” custom_margin__hover=”30px||||false|false” border_color_all__hover_enabled=”on|desktop” border_color_all__hover=”#ffb612″ theme_builder_area=”post_content” sticky_enabled=”0″][et_pb_column type=”3_4″ _builder_version=”4.20.4″ background_color=”#ffffff” custom_padding=”60px||60px|5%” custom_padding_tablet=”40px|40px|40px|40px” custom_padding_phone=”40px|40px|40px|40px” custom_padding_last_edited=”on|tablet” hover_enabled=”0″ global_colors_info=”{}” padding_tablet=”40px|40px|40px|40px” padding_last_edited=”on|tablet” custom_padding__hover=”|||” padding_phone=”40px|40px|40px|40px” theme_builder_area=”post_content” sticky_enabled=”0″][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” - [DNA](https://pascoallab.org/our-lab/) - [et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” prev_background_color=”#ffffff” next_background_color=”#ffffff” admin_label=”Hero Section” _builder_version=”4.18.0″ use_background_color_gradient=”on” background_color_gradient_type=”circular” background_color_gradient_direction_radial=”top left” background_color_gradient_stops=”#000000 12%|rgba(43,48,58,0.5) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#2b303a” background_color_gradient_start_position=”10%” background_color_gradient_end=”rgba(43,48,58,0.5)” background_image=”https://ideasci.zimmer-lab.org/wp-content/uploads/2022/10/Design-sem-nome-69.png” module_alignment=”right” custom_margin=”0px|0px|0px|0px|true|true” custom_margin_tablet=”0px|0px|0px|0px|true|true” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” custom_padding=”10vw|0|10vw|0|true|false” custom_padding_tablet=”|||0px” custom_padding_phone=”120px||120px||true” top_divider_style=”asymmetric4″ top_divider_repeat=”0.5x” top_divider_flip=”vertical” bottom_divider_style=”asymmetric4″ bottom_divider_repeat=”0.5x” bottom_divider_flip=”horizontal” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”2%” locked=”off” global_colors_info=”{}”][et_pb_row admin_label=”Hero Area” _builder_version=”4.18.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”4.18.0″ text_font=”||||||||” - [Collaborations](https://pascoallab.org/collaborations/) - [et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” prev_background_color=”#ffffff” next_background_color=”rgba(0,0,0,0.03)” admin_label=”Hero Section” _builder_version=”4.18.0″ use_background_color_gradient=”on” background_color_gradient_type=”circular” background_color_gradient_direction_radial=”top left” background_color_gradient_stops=”#000000 10%|rgba(43,48,58,0.5) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#2b303a” background_color_gradient_start_position=”10%” background_color_gradient_end=”rgba(43,48,58,0.5)” background_image=”https://ideasci.zimmer-lab.org/wp-content/uploads/2022/09/Design-sem-nome-62.png” module_alignment=”right” custom_margin=”0px|0px|0px|0px|true|true” custom_margin_tablet=”0px|0px|0px|0px|true|true” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” custom_padding=”10vw|0|10vw|0|true|false” custom_padding_tablet=”|||0px” custom_padding_phone=”120px||120px||true” top_divider_style=”asymmetric4″ top_divider_repeat=”0.5x” top_divider_flip=”vertical” bottom_divider_style=”asymmetric4″ bottom_divider_repeat=”0.5x” bottom_divider_flip=”horizontal” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”2%” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_row admin_label=”Hero Area” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”4.18.0″ - [Lab](https://pascoallab.org/lab/) ## Publications - [Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort](https://pubmed.ncbi.nlm.nih.gov/40713737/#new_tab) - Menayit Tamrat Dresse, Pamela C L Ferreira, Akshay Prasadan, Jihui L Diaz, Xuemei Zeng, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, M Ilyas Kamboh, Ann D Cohen, Tharick A Pascoal, Mary Ganguli, Beth E Snitz, C Elizabeth Shaaban, Thomas K KarikariAlzheimers Res Ther - [Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers](https://pubmed.ncbi.nlm.nih.gov/40635030/#new_tab) - Dobrin Nedelkov, Zoe E Tsokolas, Matheus Scarpatto Rodrigues, Isabel Sible, S Duke Han, Bilal E Kerman, Michael Renteln, Wendy J Mack, Tharick A Pascoal, Hussein N YassineAlzheimers Res Ther - [Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum](https://pubmed.ncbi.nlm.nih.gov/39879633/#new_tab) - Jaime Fernández Arias, Wagner S Brum, Gemma Salvadó, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Etienne Aumont, Nesrine Rahmouni, Arthur C Macedo, Kely Monica Quispialaya, Seyyed Ali Hosseini, Peter Kunach, Wan Lu Jia, Tevy Chan, Lydia Trudel, Brandon Hall, Yanseng Zheng, Sejal Mohapatra, Sulantha S Mathotaarachchi, Paolo Vitali, Cécile Tissot, Gleb Bezgin, Yasser Iturria-Medina, Nicholas J - [Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community](https://pubmed.ncbi.nlm.nih.gov/40665482/#new_tab) - Anuradha Sehrawat, Xuemei Zeng, Eric E Abrahamson, Rebecca A Deek, Alexandra Gogola, M Ilyas Kamboh, Tharick A Pascoal, Victor L Villemagne, Oscar L Lopez, Milos D Ikonomovic, Beth E Snitz, Ann D Cohen, Thomas K KarikariAlzheimers Dement - [Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/40631440/#new_tab) - Alexandra Gogola, Xuemei Zeng, Lilcelia A Williams, Theresa Chapple-McGruder, Anum Saeed, Brian J Lopresti, Beth Snitz, Dana Tudorascu, Davneet Minhas, Milos D Ikonomovic, Julia Kofler, Cristy Matan, Tharick A Pascoal, Howard Aizenstein, Henrik Zetterberg, Kaj Blennow, Oscar Lopez, Victor L Villemagne, Thomas K Karikari, Ann D CohenAlzheimers Dement - [Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/40593718/#new_tab) - Francieli Rohden, Pamela C L Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano S Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Z Lussier, Douglas T Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Dana L Tudorascu, Henrik Zetterberg, Kaj - [Pittsburgh plasma p-tau217: classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community](https://pubmed.ncbi.nlm.nih.gov/40385398/#new_tab) - Anuradha Sehrawat, Xuemei Zeng, Eric E Abrahamson, Rebecca A Deek, Alexandra Gogola, M Ilyas Kamboh, Tharick A Pascoal, Victor L Villemagne, Oscar L Lopez, Milos D Ikonomovic, Beth E Snitz, Ann D Cohen, Thomas K Karikari - [Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/40346617/#new_tab) - Bruna Bellaver, Guilherme Povala, Pamela C L Ferreira, Guilherme Bauer-Negrini, Firoza Z Lussier, Douglas T Leffa, João Pedro Ferrari-Souza, Matheus S Rodrigues, Livia Amaral, Markley S Oliveira, Carolina Soares, Andreia Rocha, Pampa Saha, Nesrine Rahmouni, Arthur Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jesse Klostranec, Maxime Montembeault, Andréa L Benedet, Nicholas J Ashton, Rebecca Langhough - [Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort](https://pubmed.ncbi.nlm.nih.gov/40343022/#new_tab) - Menayit Tamrat Dresse, Pamela C L Ferreira, Akshay Prasadan, Jihui L Diaz, Xuemei Zeng, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, M Ilyas Kamboh, Ann D Cohen, Tharick A Pascoal, Mary Ganguli, Beth E Snitz, C Elizabeth Shaaban, Thomas K Karikari - [Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology](https://pubmed.ncbi.nlm.nih.gov/40274672/#new_tab) - Gleb Bezgin, Tharick A Pascoal, Joseph Therriault, Firoza Z Lussier, Stijn Servaes, Min Su Kang, Mélissa Savard, Cécile Tissot, Jenna Stevenson, Yi-Ting Wang, Julie Ottoy, Nesrine Rahmouni, Jaime Fernandez-Arias, Seyyed Ali Hosseini, Étienne Aumont, Brandon Hall, Nina Margherita Poltronetti, Vanessa Pallen, Andréa Lessa Benedet, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Thomas K Karikari, Tatsuhiro - [Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/40289873/#new_tab) - Ilaria Pola, Nicholas J Ashton, Marco Antônio De Bastiani, Wagner S Brum, Nesrine Rahmouni, Kubra Tan, Luiza Santos Machado, Stijn Servaes, Jenna Stevenson, Cécile Tissot, Joseph Therriault, Tharick A Pascoal, Kaj Blennow, Henrik Zetterberg, Eduardo R Zimmer, Pedro Rosa-Neto, Andréa L BenedetAlzheimers Dement - [Autoradiographic comparison between [11C]PiB and [18F]AZD4694 in human brain tissue](https://pubmed.ncbi.nlm.nih.gov/40167827/#new_tab) - Antonio Aliaga, Joseph Therriault, Kely Quispialaya, Arturo Aliaga, Peter Kunach, Arthur C Macedo, Robert Hopewell, Nesrine Rahmouni, Jean-Paul Soucy, Gassan Massarweh, Marie-Christine Guiot, Tevy Chan, Jesse Klostranec, Aida Mary Abreu Diaz, Andreia Rocha, Giovanna Carello-Collar, Luiza S Machado, Marco Antônio De Bastiani, Débora Guerini de Souza, Diogo O Souza, Aline R Zimmer, Serge Gauthier, Tharick - [In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer's disease continuum](https://pubmed.ncbi.nlm.nih.gov/40196010/#new_tab) - Douglas Leffa, Guilherme Povala, Pamela Ferreira, João Pedro Ferrari-Souza, Guilherme Bauer-Negrini, Matheus Rodrigues, Livia Amaral, Firoza Lussier, Marina Medeiros, Carolina Soares, Cristiano S Aguzzoli, Arthur Macedo, Joseph Therriault, Pedro Rosa-Neto, Dana Tudorascu, Eduardo Zimmer, Bruna Bellaver, Tharick Pascoal - [Biofluid-based staging of Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/40095069/#new_tab) - Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Nicholas J Ashton, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Wagner S Brum, Stijn Servaes, Jenna Stevenson, Guglielmo Di Molfetta, Burak Arslan, Jesse Klostranec, Paolo Vitali, Maxime Montembeault, Serge Gauthier, Cecile Tissot, Arthur C Macedo, Tharick A Pascoal, Andreas Jeromin, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L BenedetActa Neuropathol - [Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/40473528/#new_tab) - Sarah Abbas, Pamela C L Ferreira, Bruna Bellaver, Guilherme Povala, Francieli Rohden, Cristiano Schaffer Aguzzoli, Hussein Zalzale, João Pedro Ferrari-Souza, Douglas T Leffa, Firoza Z Lussier, Carolina Soares, Guilherme Bauer-Negrini, Markley Silva Oliveira-Junior, Matheus Scarpatto Rodrigues, Pampa Saha, Emma Ruppert, Marina Scop Medeiros, Cécile Tissot, Joseph Therriault, Nesrine Rahmouni, Stijn Servaes, Andrea L Benedet, Nicholas - [Diagnostic performance of Alzheimer's disease blood and CSF biomarkers in a Brazilian cohort with low educational attainment](https://pubmed.ncbi.nlm.nih.gov/40921793/#new_tab) - Wyllians Vendramini Borelli, Pamela C L Ferreira, Wagner S Brum, João Pedro Ferrari-Souza, Giovanna Carello-Collar, Maila Holz, Victoria Tizeli, Matheus Zschornack Strelow, Carolina Formoso, Marcia Lorena Fagundes Chaves, Andreia Rocha, Cristiano Schaffer Aguzzoli, Francieli Rohden, Débora G Souza, Artur Francisco Schumacher Schuh, Guilherme Povala, Bruna Bellaver, Pedro Rosa-Neto, Raphael Machado Castilhos, Tharick A Pascoal, Eduardo - [Comparison of Plasma p-tau217 and [18F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia](https://pubmed.ncbi.nlm.nih.gov/39715476/#new_tab) - Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Andrea L Benedet, Nicholas J Ashton, Thomas Karikari, Arthur Cassa Macedo, Nesrine Rahmouni, Cécile Tissot, Jaime Fernandez Arias, Yi-Ting Tina Wang, Lydia Trudel, Seyyed Ali Hosseini, Takashi Matsudaira, Tevy Chan, Tharick Pascoal, Brian Gilfix, Paolo Vitali, Eduardo R Zimmer, Karine Provost, Jean-Paul Soucy, Serge Gauthier, Henrik Zetterberg, Bertrand - [Comparison Between Brain and Cerebellar Autoradiography Using [18F]Flortaucipir, [18F]MK6240, and [18F]PI2620 in Postmortem Human Brain Tissue](https://pubmed.ncbi.nlm.nih.gov/39477493/#new_tab) - Antonio Aliaga, Joseph Therriault, Kely Monica Quispialaya, Arturo Aliaga, Robert Hopewell, Nesrine Rahmouni, Arthur C Macedo, Peter Kunach, Jean-Paul Soucy, Gassan Massarweh, Aida Abreu Diaz, Tharick A Pascoal, Andreia Rocha, Marie-Christine Guiot, Luiza S Machado, Marco Antônio De Bastiani, Débora Guerini de Souza, Diogo O Souza, Serge Gauthier, Eduardo R Zimmer, Pedro Rosa-NetoJ Nucl Med. - [Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults](https://pubmed.ncbi.nlm.nih.gov/40042417/#new_tab) - Antonija Kolobaric, Carmen Andreescu, Andrew R Gerlach, Eldin Jašarević, Howard Aizenstein, Tharick A Pascoal, Pamela C L Ferreira, Bruna Bellaver, Chang Hyung Hong, Hyun Woong Roh, Yong Hyuk Cho, Sunhwa Hong, You Jin Nam, Bumhee Park, Dong Yun Lee, Narae Kim, Jin Wook Choi, Sang Joon Son, Helmet T Karim Alzheimers Dement - [Brain age mediates gut microbiome dysbiosis-related cognition in older adults](https://pubmed.ncbi.nlm.nih.gov/40016766/#new_tab) - Sang Joon Son, Dong Yun Lee, Hyun Woong Roh, Maria Ly, Antonija Kolobaric, Howard Aizenstein, Carmen Andreescu, Eldin Jašarević, Tharick A Pascoal, Pamela C L Ferreira, Bruna Bellaver, Yong Hyuk Cho, Sunhwa Hong, You Jin Nam, Bumhee Park, Narae Kim, Jin Wook Choi, Jae Youn Cheong, Yoon-Keun Kim, Tae-Seop Shin, Chil-Sung Kang, Cheol-O Kwon, Seo-Yoon - [Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/39998851/#new_tab) - Douglas T Leffa, Guilherme Povala, Bruna Bellaver, João Pedro Ferrari-Souza, Pamela C L Ferreira, Firoza Z Lussier, Cristiano Schaffer Aguzzoli, Carolina Soares, Hussein Zalzale, Francieli Rohden, Guilherme Bauer-Negrini, Sarah Abbas, Maitê Schneider, Joseph Therriault, Oscar L Lopez, Victor L Villemagne, William E Klunk, Dana L Tudorascu, Ann D Cohen, Pedro Rosa-Neto, Eduardo R Zimmer, Thomas - [Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/39930142/#new_tab) - Tohidul Islam, Emily Hill, Eric E Abrahamson, Stijn Servaes, Denis S Smirnov, Xuemei Zeng, Anuradha Sehrawat, Yijun Chen, Przemysław R Kac, Hlin Kvartsberg, Maria Olsson, Emma Sjons, Fernando Gonzalez-Ortiz, Joseph Therriault, Cécile Tissot, Ivana Del Popolo, Nesrine Rahmouni, Abbie Richardson, Victoria Mitchell, Henrik Zetterberg, Tharick A Pascoal, Tammaryn Lashley, Mark J Wall, Douglas Galasko, Pedro - [Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries](https://pubmed.ncbi.nlm.nih.gov/39890228/#new_tab) - Lucas U Da Ros, Wyllians Vendramini Borelli, Cristiano Schaffer Aguzzoli, Marco Antônio De Bastiani, Lucas Porcello Schilling, Hernando Santamaria-Garcia, Tharick A Pascoal, Pedro Rosa-Neto, Diogo O Souza, Jaderson Costa da Costa, Agustin Ibañez, Claudia Kimie Suemoto, Eduardo R Zimmer Lancet Glob Health - [Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay](https://pubmed.ncbi.nlm.nih.gov/39845736/#new_tab) - Yi-Ting Wang, Nicholas J Ashton, Joseph Therriault, Andréa L Benedet, Arthur C Macedo, Ilaria Pola, Etienne Aumont, Guglielmo Di Molfetta, Jaime Fernandez-Arias, Kubra Tan, Nesrine Rahmouni, Stijn Johannes G Servaes, Richard Isaacson, Tevy Chan, Seyyed Ali Hosseini, Cécile Tissot, Sulantha Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Tharick A Pascoal, Serge Gauthier, Kaj Blennow, Henrik Zetterberg, - [Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability](https://pubmed.ncbi.nlm.nih.gov/39533113/#new_tab) - Joseph Therriault, Shorena Janelidze, Andréa Lessa Benedet, Nicholas J Ashton, Javier Arranz Martínez, Armand Gonzalez-Escalante, Bruna Bellaver, Daniel Alcolea, Agathe Vrillon, Helmet Karim, Michelle M Mielke, Chang Hyung Hong, Hyun Woong Roh, José Contador, Albert Puig Pijoan, Alicia Algeciras-Schimnich, Prashanthi Vemuri, Jonathan Graff-Radford, Val J Lowe, Thomas K Karikari, Erin Jonaitis, Wagner Brum, Cécile Tissot, - [Identification of late-stage tau accumulation using plasma phospho-tau217](https://pubmed.ncbi.nlm.nih.gov/39500009/#new_tab) - Marcel S Woo, Joseph Therriault, Erin M Jonaitis, Rachael Wilson, Rebecca E Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J Betthauser, Firoza Z Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C Kolb, Andreas Jeromin, Eliane Kobayashi, - [Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer disease](https://pubmed.ncbi.nlm.nih.gov/39447157/#new_tab) - Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Thomas K Karikari, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Firoza Z Lussier, Jenna Stevenson, Yi-Ting Wang, Jaime Fernandez Arias, Ali Hosseini, Takashi Matsudaira, Bertrand Jean-Claude, Brian M Gilfix, Eduardo R Zimmer, Jean-Paul Soucy, Tharick A Pascoal, Serge Gauthier, Henrik - [Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/39385222/#new_tab) - Xuemei Zeng, Tara K Lafferty, Anuradha Sehrawat, Yijun Chen, Pamela C L Ferreira, Bruna Bellaver, Guilherme Povala, M Ilyas Kamboh, William E Klunk, Ann D Cohen, Oscar L Lopez, Milos D Ikonomovic, Tharick A Pascoal, Mary Ganguli, Victor L Villemagne, Beth E Snitz, Thomas K Karikari Mol Neurodegener. - [Insights into the use of biomarkers in clinical trials in Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/39366844/#new_tab) - Tharick A Pascoal, Cristiano S Aguzzoli, Firoza Z Lussier, Lucía Crivelli, Claudia K Suemoto, Juan Fortea, Pedro Rosa-Neto, Eduardo R Zimmer, Pamela C L Ferreira, Bruna Bellaver EBioMedicine - [Association of plasma biomarkers of Alzheimer's disease and related disorders with cognition and cognitive decline: The MYHAT population-based study](https://pubmed.ncbi.nlm.nih.gov/38753951/#new_tab) - Yingjin Zhang, Pamela C L Ferreira, Erin Jacobsen, Bruna Bellaver, Tharick A Pascoal, Beth E Snitz, Chung-Chou H Chang, Victor L Villemagne, Mary Ganguli, Thomas K Karikari Alzheimer's & Dementia - [Tau follows principal axes of functional and structural brain organization in Alzheimer's disease](https://www.nature.com/articles/s41467-024-49300-2#new_tab) - Julie Ottoy, Min Su Kang, Jazlynn Xiu Min Tan, Lyndon Boone, Reinder Vos de Wael, Bo-yong Park, Gleb Bezgin, Firoza Z. Lussier, Tharick A. Pascoal, Nesrine Rahmouni, Jenna Stevenson, Jaime Fernandez Arias, Joseph Therriault, Seok-Jun Hong, Bojana Stefanovic, JoAnne McLaurin, Jean-Paul Soucy, Serge Gauthier, Boris C. Bernhardt, Sandra E. Black, Pedro Rosa-Neto & Maged Goubran - [Omics-derived biological modules reflect metabolic brain changes in Alzheimer's disease](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14095#new_tab) - Guilherme Povala, Marco Antônio De Bastiani, Bruna Bellaver, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Firoza Z. Lussier, Diogo O. Souza, Pedro Rosa-Neto, Tharick A. Pascoal, Bruno Zatt, Eduardo R. Zimmer, for the Alzheimer's Disease Neuroimaging Initiative Alzheimer's & Dementia - [Cross-species comparative hippocampal transcriptomics in Alzheimer's disease](https://www.sciencedirect.com/science/article/pii/S2589004223027487?via=ihub#new_tab) - Marco Antônio De Bastiani, Bruna Bellaver, Giovanna Carello-Collar, Maria Zimmermann, Peter Kunach, Ricardo A.S. Lima-Filho, Stefania Forner, Alessandra Cadete Martini, Tharick A. Pascoal, Mychael V. Lourenco, Pedro Rosa-Neto, Eduardo R. Zimmer iScience - [The relation of synapticbiomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer's disease](https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00420-1#:~:text=The results of this study,dysfunction and degeneration in AD.#new_tab) - Wang YT, Ashton NJ, Servaes S, Nilsson J, Woo MS, Pascoal TA, Tissot C, Rahmouni N, Therriault J, Lussier F, Chamoun M, Gauthier S, Brinkmalm A, Zetterberg H, Blennow K, Rosa-Neto P, Benedet AL. Transl Neurodegener. - [Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical Research](https://pubmed.ncbi.nlm.nih.gov/39167736/#new_tab) - Andrei Bieger, Wagner S Brum, Wyllians V Borelli, Joseph Therriault, Marco A De Bastiani, Amanda G Moreira, Andrea L Benedet, João Pedro Ferrari-Souza, Jaderson C Da Costa, Diogo O Souza, Raphael M Castilhos, Artur Francisco Schumacher Schuh, Marcia L Fagundes Chaves, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Neto, Lucas - [Modeling the progression of neuropsychiatric symptoms in Alzheimer's disease with PET-based Braak staging](https://pubmed.ncbi.nlm.nih.gov/39326302/#new_tab) - Arthur C Macedo, Joseph Therriault, Cécile Tissot, Étienne Aumont, Stijn Servaes, Nesrine Rahmouni, Jaime Fernandez-Arias, Firoza Z Lussier, Yi-Ting Wang, Kok Pin Ng, Marie Vermeiren, Gleb Bezgin, Kely Quispialaya Socualaya, Jenna Stevenson 1, Seyyed Ali Hosseini, Mira Chamoun, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas Teixeira Leffa, Paolo Vitali, Eduardo R Zimmer, - [Reduction in Constitutively Activated Auditory Brainstem Microglia inAging and Alzheimer's Disease](https://pubmed.ncbi.nlm.nih.gov/38669537/#new_tab) - Butler T, Wang X, Chiang G, Xi K, Niogi S, Glodzik L, Li Y, Razlighi QR, Zhou L, Hojjati SH, Ozsahin I, Mao X, Maloney T, Tanzi E, Rahmouni N, Tissot C, Lussier F, Shah S, Shungu D, Gupta A, De Leon M, Mozley PD, Pascoal TA, Rosa- Neto P. J Alzheimers Dis. - [Plasma pTau-217 and N-terminal tau (NTA) enhancesensitivity to identify tau PET positivity in amyloid-β positive individuals](https://pubmed.ncbi.nlm.nih.gov/37920945/#new_tab) - Woo MS, Tissot C, Lantero-Rodriguez J, Snellman A, Therriault J, Rahmouni N, Macedo AC, Servaes S, Wang YT, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Benedet AL, Ashton NJ, Karikari TK, Triana-Baltzer G, Kolb HC, Stevenson J,Mayer C, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P. - [A novelultrasensitive assay for plasma p-tau217: Performance in individuals withsubjective cognitive decline and early Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/37975513/#new_tab) - Gonzalez-Ortiz F, Ferreira PCL, González-Escalante A, Montoliu-Gaya L, Ortiz-Romero P, Kac PR, Turton M, Kvartsberg H, Ashton NJ, Zetterberg H,Harrison P, Bellaver B, Povala G, Villemagne VL, Pascoal TA, Ganguli M, Cohen AD, Minguillon C, Contador J, Suárez-Calvet M, Karikari TK, Blennow K. Alzheimers Dement. - [The glutamatergic system in Alzheimer's disease: asystematic review with meta-analysis.](https://pubmed.ncbi.nlm.nih.gov/38366114/#new_tab) - Soares C, Da Ros LU, Machado LS, Rocha A, Lazzarotto G, Carello-Collar G, De Bastiani MA, Ferrari-Souza JP, Lussier FZ, Souza DO, Rosa-Neto P, Pascoal TA, Bellaver B, Zimmer ER. Mol Psychiatry. - [Predicting functional decline in aging and Alzheimer's diseasewith PET-based Braak staging](https://watermark.silverchair.com/fcae043.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA2EwggNdBgkqhkiG9w0BBwagggNOMIIDSgIBADCCA0MGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMxleUn-KZhMoxRC8-AgEQgIIDFOfm2INYlTKPn9IiYWE0Esie0MpEdaqqfUHLk4UlYvZPK0sKDmFotZZkId-oL3S-QbZqdaxuoUP31NfCSOotB6PVsmki6OfW1XSA32VHmHfWm9wd58p7340Y7HzsY3baQbE3zv-YbcAX5-0j52sPOBoxcH62cDzXa9tKUCNiN_7o4EBIL3GqLG5uV6OC2GPtgr_099nstn0zsvpT_An2LTVydo6blO9CjyQuaA4lDXoFdZgxHGie54ywa1wUcGvBTJ4-MZJSDpYt4iOU-cVaZofF-bhCISl6q1jd-jbTFb-oONzpeYlAYfu2mJpVpHdM3ouaXDzHeNiOqhKAEEbADVP8OK83a1-OoD82zsldjc_vcAn6UFwgzKaXU2pJbjIlj0deHJt8cF_4eFW_xXcIdRO3ROILueBwScFAfUGdmvqpzDs1EfXnMfGFENP3uub3UAPndayE2BhhR5LUafCSBYSrB-m4rGjSkD7YG9GbtM0bIyYiq_AcRdijeTe-ulPOvMPMWCyYcRS-4ahT8PaL_nsPEUZTNaXxMNJertp4eFadJv695B-1xh7bZhMqF0okUFH3ZnnkgeqWBjomEOx8savcDSuKDe0eV5ehxpS1nVAD29uI1JEQ79Xwv37Md4gw4jkJpLvTo_WQQLf8DKRVqvbKY6rJMiwYhCH8nS3yevusac617uujbTCH2zPbZj9FcJg9VDye8fpOVpogQTHLRM6ZMVyX-vFu4HPoo1OOP2iOZ2r0h37ZJMQzgvf9_O3HYybRFXzyJI-mZh3zpmHf5-OrvKlHkK6S0TVmkaHOdJ0b422nU0u5bDCV67zRrA-KleaRuwfXUjuHemtHmJ83DJ9EMWD8GEJZBv9qCBPqRNXfwwUoiXUWzYpgtx66eVToSU4Z7JAuNMFnwAEsV-gbPIKY4LsbehMRmWqp-dX5gZ0cStfHU1mJ1G8IG7Iv1G-Hdu04NsNIT53rr2OfgelrHvfZNE_Ywn9_IvL940lV9wZUPSDb9G3jUs4qR2zQp-4pI8Jkeomla1HzpCgZ0tcN53kLNSBZ#new_tab) - Macedo AC, Therriault J, Tissot C, Fernandez-Arias J, Ferreira PCL, Vitali P, Servaes S, Rahmouni N, Vermeiren M, Bezgin G, Lussier FZ, Stevenson J, Wang YT, Socualaya KQ, Kunach P, Nazneen T, Hosseini SA, Pallen V, Stevenson A, Ferrari-Souza JP, Bellaver B, Leffa DT, Ng KP, Zimmer ER, Pascoal TA, Gauthier S, Rosa-Neto P. Brain - [Alzheimer’s DiseaseNeuroimaging Initiative. Vascular risk burden is a key player in the earlyprogression of Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/38335912/#new_tab) - Ferrari-Souza JP, Brum WS, Hauschild LA, Da Ros LU, Ferreira PCL, Bellaver B, Leffa DT, Bieger A, Tissot C, Lussier FZ, De Bastiani MA, Povala G, Benedet AL, Therriault J, Wang YT, Ashton NJ, Zetterberg H, Blennow K, Martins SO, Souza DO,Rosa-Neto P, Karikari TK, Pascoal TA, Zimmer ER Neurobiol Aging. - [Biomarker-based staging ofAlzheimer disease: rationale and clinical applications](https://pubmed.ncbi.nlm.nih.gov/38429551/#new_tab) - Therriault J, Schindler SE, Salvadó G, Pascoal TA, Benedet AL, Ashton NJ, Karikari TK, Apostolova L, Murray ME, Verberk I, Vogel JW, La Joie R, Gauthier S, Teunissen C, Rabinovici GD, Zetterberg H, Bateman RJ, Scheltens P, Blennow K, Sperling R, Hansson O, Jack CR Jr, Rosa-Neto P. Nat Rev Neurol. - [Comparisonof two plasma p-tau217 assays to detect and monitor Alzheimer's pathology](https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00081-1/fulltext#new_tab) - Therriault J, Ashton NJ, Pola I, Triana-Baltzer G, Brum WS, Di Molfetta G, Arslan B, Rahmouni N, Tissot C, Servaes S, Stevenson J, Macedo AC, Pascoal TA, Kolb HC, Jeromin A, Blennow K, Zetterberg H, Rosa-Neto P, Benedet AL. EBioMedicine. - [Alzheimer’s Disease Neuroimaging Initiative. Sex-specific modulation ofamyloid-β on tau phosphorylation underlies faster tangle accumulation infemales](https://pubmed.ncbi.nlm.nih.gov/37988283/#new_tab) - Wang YT, Therriault J, Servaes S, Tissot C, Rahmouni N, Macedo AC, Fernandez- Arias J, Mathotaarachchi SS, Benedet AL, Stevenson J, Ashton NJ, Lussier FZ, Pascoal TA, Zetterberg H, Rajah MN, Blennow K, Gauthier S, Rosa-Neto P. Brain. - [Sex differences in Alzheimer's disease blood biomarkers in a Caribbean population of African ancestry: The Tobago Health Study](https://pubmed.ncbi.nlm.nih.gov/38617114/#new_tab) - Rosano C, Karikari TK, Cvejkus R, Bellaver B, Ferreira PCL, Zmuda J, Wheeler V, Pascoal TA, Miljkovic I. Alzheimers Dement. - [Alzheimer blood biomarkers: practical guidelines for study design, samplecollection, processing, biobanking, measurement and result reporting](https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-024-00711-1#new_tab) - Zeng X, Chen Y, Sehrawat A, Lee J, Lafferty TK, Kofler J, Berman SB, Sweet RA, Tudorascu DL, Klunk WE, Ikonomovic MD, Pfister A, Zetterberg H, Snitz BE, Cohen AD, Villemagne VL, Pascoal TA, Kamboh ML, Lopez OI, Blennow K, Karikari TK. Mol Neurodegener. - [Association of plasma biomarkers ofAlzheimer's disease and related disorders with cognition and cognitive decline:The MYHAT population-based study](https://pubmed.ncbi.nlm.nih.gov/38753951/#new_tab) - Zhang Y, Ferreira PCL, Jacobsen E, Bellaver B, Pascoal TA, Snitz BE, Chang CH, Villemagne VL, Ganguli M, Karikari TK. Alzheimers Dement. - [Effect ofblood collection tube containing protease inhibitors on the pre-analyticalstability of Alzheimer's disease plasma biomarkers](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942510/#new_tab) - Chen Y, Zeng X, Diaz JL, Sehrawat A, Lafferty TK, Boslett JJ, Klunk WE, Pascoal TA, Villemagne VL, Cohen AD, Lopez OI, Yates NA, Karikari TK J Neurochem. - [Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology](https://jamanetwork.com/journals/jamaneurology/fullarticle/2813751#new_tab) - Nicholas J. Ashton, Wagner S. Brum, Guglielmo Di Molfetta, Andrea L. Benedet, Burak Arslan, Erin Jonaitis, Rebecca E. Langhough, Karly Cody, Rachael Wilson, Cynthia M. Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas - [Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773025/#new_tab) - Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge - [Association Between β-Amyloid Accumulation and Incident Dementia in Individuals 80 Years or Older Without Dementia](https://www.neurology.org/doi/10.1212/WNL.0000000000207920?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed#new_tab) - Oscar L. Lopez, Victor L. Villemagne, Yue-Fang Chang, Ann D. Cohen, William E. Klunk, Chester A. Mathis, Tharick Pascoal, Milos D. Ikonomovic, Christopher Rowe, Vincent Dore, Beth E. Snitz, Brian J. Lopresti, MSNEM M. Ilyas Kamboh, Howard J. Aizenstein, Lewis H. Kuller Neurology - [Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812154#new_tab) - Cristiano Schaffer Aguzzoli, MD; Pâmela C. L. Ferreira, PhD; Guilherme Povala, PhD; João Pedro Ferrari-Souza; Bruna Bellaver, PhD; Carolina Soares Katz, MSc; Hussein Zalzale, MSc; Firoza Z. Lussier, MSc; Francieli Rohden, PhD; Sarah Abbas, MD; Douglas T. Leffa, PhD; Marina Scop Medeiros, MD; Joseph Therriault, PhD; Andréa L. Benedet, PhD; Cécile Tissot, PhD; Stijn Servaes, - [APOEε4 potentiates amyloid β effects on longitudinal tau pathology](https://www.nature.com/articles/s43587-023-00490-2#new_tab) - João Pedro Ferrari-Souza, Bruna Bellaver, Pâmela C. L. Ferreira, Andréa L. Benedet, Guilherme Povala, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Carolina Soares, Yi-Ting Wang, Mira Chamoun, Stijn Servaes, Arthur C. Macedo, Marie Vermeiren, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, Ann Cohen, Oscar L. - [Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13393#new_tab) - Pamela C. L. Ferreira, Joseph Therriault, Cécile Tissot, João Pedro Ferrari-Souza, Andréa L. Benedet, Guilherme Povala, Bruna Bellaver, Douglas T. Leffa, Wagner S. Brum, Firoza Z. Lussier, Gleb Bezgin, Stijn Servaes, Marie Vermeiren, Arthur C. Macedo, Arlec Cabrera, Jenna Stevenson, Gallen Triana-Baltzer, Hartmuth Kolb, Nesrine Rahmouni, William E. Klunk, Oscar L. Lopez, Victor L. Villemagne, - [Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies](https://pubmed.ncbi.nlm.nih.gov/37198279/#new_tab) - Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blennow Nat Aging. 2023 - [The GABAergic system in Alzheimer's disease: a systematic review with meta-analysis](https://pubmed.ncbi.nlm.nih.gov/37419974/#new_tab) - Giovanna Carello-Collar, Bruna Bellaver, Pamela C L Ferreira, João Pedro Ferrari-Souza, Vanessa G Ramos, Joseph Therriault, Cécile Tissot, Marco A De Bastiani, Carolina Soares, Tharick A Pascoal, Pedro Rosa-Neto, Diogo O Souza, Eduardo R Zimmer Mol Psychiatry. 2023 - [The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework](https://pubmed.ncbi.nlm.nih.gov/37321820/#new_tab) - Arthur C Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R Zimmer, Marie-Christine Guiot, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Neto J Nucl Med. 2023 - [Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease](https://www.nature.com/articles/s41591-023-02380-x#new_tab) - Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Andréa L. Benedet, Nicholas J. Ashton, Gallen Triana-Baltzer, Hartmuth C. Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L. Lopez, Dana L. Tudorascu, Victor L. Villemagne, Milos D. Ikonomovic, Serge Gauthier, Eduardo R. Zimmer, - [APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles](https://www.science.org/doi/10.1126/sciadv.ade1474#new_tab) - João Pedro Ferrari-Souza, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela C. L. Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L. Benedet, Nicholas J. Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, JennaStevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T. O’Brien, James B. Rowe, Ann - [Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials](https://n.neurology.org/content/early/2023/03/06/WNL.0000000000207115#new_tab) - Pamela Ferreira, João Pedro Ferrari-Souza, Cécile Tissot, Bruna Bellaver, Douglas Leffa, Firoza Lussier,Guilherme Povala, Joseph Therriault, Andréa L Benedet, Nicholas J Ashton, Ann D. Cohen, Oscar L. Lopez, Dana Tudorascu, William E. Klunk, Jean-Paul Soucy, Serge Gauthier, Victor Villemagne, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Eduardo R. Zimmer, Thomas K Karikari, Tharick Pascoal, for the Alzheimer's Disease Neuroimaging Initiative Neurology DOI: 10.1212/WNL.0000000000207115 - [Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies](https://www.sciencedirect.com/science/article/pii/S0889159123000582?via=ihub#new_tab) - Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G. Souza, Pamela C.L. Ferreira, Andreia S. Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L. Benedet, Nicholas J. Ashton, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A. Pascoal, Eduardo R. Zimmer, for the Alzheimer's Disease Neuroimaging Initiative Brain Behavior and Immunity May - [Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology](https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13014#new_tab) - Bruna Bellaver, Albert Puig-Pijoan, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cécile Tissot, Guilherme Povala, Joseph Therriault, Andréa L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suárez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal. Alzheimer's & Dementia 15 March 2023 https://doi.org/10.1002/alz.13014 - [Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy.](https://pubmed.ncbi.nlm.nih.gov/23533871/#new_tab) - Porcello Marrone LC, Marrone BF, Pascoal TA, Schilling LP, Soder RB, Ferreira SS, Gadonski G, da Costa JC. Case Rep Oncol Med. 2013;2013:306983. doi: 10.1155/2013/306983. Epub 2013 Feb 27. - [Bilateral perisylvian ulegyria: an under-recognized, surgically remediable epileptic syndrome.](https://pubmed.ncbi.nlm.nih.gov/23586600/#new_tab) - Schilling LP, Kieling RR, Pascoal TA, Kim HI, Lee MC, Kim YH, Paglioli E, Neto PR, Costa JC, Palmini A. Epilepsia. 2013 Aug;54(8):1360-7. doi: 10.1111/epi.12160. Epub 2013 Apr 15. - [Posterior reversible encephalopathy syndrome following a scorpion sting.](https://pubmed.ncbi.nlm.nih.gov/23551823/#new_tab) - Porcello Marrone LC, Marrone BF, Neto FK, Costa FC, Thomé GG, Aramburu MB, Schilling LP, Pascoal TA, Gadonski G, Huf Marrone AC, da Costa JC. J Neuroimaging. 2013 Oct;23(4):535-6. doi: 10.1111/jon.12017. Epub 2013 Apr 3. - [Epistasis analysis links immune cascades and cerebral amyloidosis.](https://pubmed.ncbi.nlm.nih.gov/26626881/#new_tab) - Benedet AL, Labbe A, Lemay P, Zimmer ER, Pascoal TA, Leuzy A, Mathotaarachchi S, Mohades S, Shin M, Dionne-Laporte A, Beaudry T, Picard C, Gauthier S, Poirier J, Rouleau G, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. J Neuroinflammation. 2015 Dec 1;12:227. doi: 10.1186/s12974-015-0436-z. - [Imaging Alzheimer's disease pathophysiology with PET.](https://pubmed.ncbi.nlm.nih.gov/29213438/#new_tab) - Schilling LP, Zimmer ER, Shin M, Leuzy A, Pascoal TA, Benedet AL, Borelli WV, Palmini A, Gauthier S, Rosa-Neto P. Dement Neuropsychol. 2016 Apr-Jun;10(2):79-90. doi: 10.1590/S1980-5764-2016DN1002003. - [VoxelStats: A MATLAB Package for Multi-Modal Voxel-Wise Brain Image Analysis.](https://pubmed.ncbi.nlm.nih.gov/27378902/#new_tab) - Mathotaarachchi S, Wang S, Shin M, Pascoal TA, Benedet AL, Kang MS, Beaudry T, Fonov VS, Gauthier S, Labbe A, Rosa-Neto P. Front Neuroinform. 2016 Jun 15;10:20. doi: 10.3389/fninf.2016.00020. eCollection 2016. - [Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/27021814/#new_tab) - Pascoal TA, Mathotaarachchi S, Mohades S, Benedet AL, Chung CO, Shin M, Wang S, Beaudry T, Kang MS, Soucy JP, Labbe A, Gauthier S, Rosa-Neto P. Mol Psychiatry. 2017 Feb;22(2):306-311. doi: 10.1038/mp.2016.37. Epub 2016 Mar 29. - [The prevalence and biomarkers' characteristic of rapidly progressive Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database.](https://pubmed.ncbi.nlm.nih.gov/29067322/#new_tab) - Ba M, Li X, Ng KP, Pascoal TA, Mathotaarachchi S, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement (N Y). 2017 Feb 9;3(1):107-113. doi: 10.1016/j.trci.2016.12.005. eCollection 2017 Jan. - [Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain.](https://pubmed.ncbi.nlm.nih.gov/28359327/#new_tab) - Ng KP, Pascoal TA, Mathotaarachchi S, Therriault J, Kang MS, Shin M, Guiot MC, Guo Q, Harada R, Comley RA, Massarweh G, Soucy JP, Okamura N, Gauthier S, Rosa-Neto P. Alzheimers Res Ther. 2017 Mar 31;9(1):25. doi: 10.1186/s13195-017-0253-y. - [Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease.](https://pubmed.ncbi.nlm.nih.gov/28404803/#new_tab) - Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative. Neurology. 2017 May 9;88(19):1814-1821. doi: 10.1212/WNL.0000000000003916. Epub 2017 Apr 12. - [Synergistic interaction between amyloid and tau predicts the progression to dementia.](https://pubmed.ncbi.nlm.nih.gov/28024995/#new_tab) - Pascoal TA, Mathotaarachchi S, Shin M, Benedet AL, Mohades S, Wang S, Beaudry T, Kang MS, Soucy JP, Labbe A, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement. 2017 Jun;13(6):644-653. doi: 10.1016/j.jalz.2016.11.005. Epub 2016 Dec 23. - [Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer's Disease.](https://pubmed.ncbi.nlm.nih.gov/28422655/#new_tab) - Dadar M, Pascoal TA, Manitsirikul S, Misquitta K, Fonov VS, Tartaglia MC, Breitner J, Rosa-Neto P, Carmichael OT, Decarli C, Collins DL. IEEE Trans Med Imaging. 2017 Aug;36(8):1758-1768. doi: 10.1109/TMI.2017.2693978. Epub 2017 Apr 12. - [Characterizing biomarker features of cognitively normal individuals with ventriculomegaly.](https://pubmed.ncbi.nlm.nih.gov/29159265/#new_tab) - Li X, Ba M, Ng KP, Mathotaarachchi S, Pascoal TA, Rosa-Neto P, Gauthier S. Alzheimers Dement (Amst). 2017 Sep 5;10:12-21. doi: 10.1016/j.dadm.2017.08.001. eCollection 2018. - [Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease.](https://pubmed.ncbi.nlm.nih.gov/29084927/#new_tab) - Gauthier S, Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedetti AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P. Neurology. 2017 Oct 31;89(18):1931. doi: 10.1212/WNL.0000000000004593. - [Identifying incipient dementia individuals using machine learning and amyloid imaging.](https://pubmed.ncbi.nlm.nih.gov/28756942/#new_tab) - Mathotaarachchi S, Pascoal TA, Shin M, Benedet AL, Kang MS, Beaudry T, Fonov VS, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Neurobiol Aging. 2017 Nov;59:80-90. doi: 10.1016/j.neurobiolaging.2017.06.027. Epub 2017 Jul 11. - [Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment.](https://pubmed.ncbi.nlm.nih.gov/29504543/#new_tab) - Gauthier S, Ng KP, Pascoal TA, Zhang H, Rosa-Neto P. J Alzheimers Dis. 2018;64(s1):S23-S31. doi: 10.3233/JAD-179924. - [CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem.](https://pubmed.ncbi.nlm.nih.gov/29473050/#new_tab) - Benedet AL, Yu L, Labbe A, Mathotaarachchi S, Pascoal TA, Shin M, Kang MS, Gauthier S, Rouleau GA, Poirier J, Bennett DA, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Neurol Genet. 2018 Jan 30;4(1):e216. doi: 10.1212/NXG.0000000000000216. eCollection 2018 Feb. - [Anosognosia predicts default mode network hypometabolism and clinical progression to dementia.](https://pubmed.ncbi.nlm.nih.gov/29444971/#new_tab) - Therriault J, Ng KP, Pascoal TA, Mathotaarachchi S, Kang MS, Struyfs H, Shin M, Benedet AL, Walpola IC, Nair V, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Neurology. 2018 Mar 13;90(11):e932-e939. doi: 10.1212/WNL.0000000000005120. Epub 2018 Feb 14. - [Impact of the biological definition of Alzheimer's disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?](https://pubmed.ncbi.nlm.nih.gov/29876101/#new_tab) - Gauthier S, Zhang H, Ng KP, Pascoal TA, Rosa-Neto P. Transl Neurodegener. 2018 May 31;7:12. doi: 10.1186/s40035-018-0117-9. eCollection 2018. - [Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/29396637/#new_tab) - Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):1021-1030. doi: 10.1007/s00259-018-3933-3. Epub 2018 Feb 2. - [In vivo quantification of neurofibrillary tangles with [18F]MK-6240.](https://pubmed.ncbi.nlm.nih.gov/30064520/#new_tab) - Pascoal TA, Shin M, Kang MS, Chamoun M, Chartrand D, Mathotaarachchi S, Bennacef I, Therriault J, Ng KP, Hopewell R, Bouhachi R, Hsiao HH, Benedet AL, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P. Alzheimers Res Ther. 2018 Jul 31;10(1):74. doi: 10.1186/s13195-018-0402-y. - [Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/30115118/#new_tab) - Zhang H, Therriault J, Kang MS, Ng KP, Pascoal TA, Rosa-Neto P, Gauthier S; Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Res Ther. 2018 Aug 16;10(1):80. doi: 10.1186/s13195-018-0407-6. - [Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/30311914/#new_tab) - Zhang H, Ng KP, Therriault J, Kang MS, Pascoal TA, Rosa-Neto P, Gauthier S; Alzheimer’s Disease Neuroimaging Initiative. Transl Neurodegener. 2018 Sep 10;7:23. doi: 10.1186/s40035-018-0127-7. eCollection 2018. - [Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [18F]THK5351 uptake in progressive supranuclear palsy.](https://pubmed.ncbi.nlm.nih.gov/31795034/#new_tab) - Ng KP, Therriault J, Kang MS, Struyfs H, Pascoal TA, Mathotaarachchi S, Shin M, Benedet AL, Massarweh G, Soucy JP, Rosa-Neto P, Gauthier S. Neuroimage Clin. 2019;24:102091. doi: 10.1016/j.nicl.2019.102091. Epub 2019 Nov 13. - [A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging.](https://pubmed.ncbi.nlm.nih.gov/30426529/#new_tab) - Hopewell R, Ross K, Kostikov A, Pascoal TA, Alberti T, Lacatus-Samoila M, Soucy JP, Bennacef I, Kobayashi E, Kang MS, Rosa-Neto P, Massarweh G. J Labelled Comp Radiopharm. 2019 Feb;62(2):109-114. doi: 10.1002/jlcr.3695. Epub 2018 Dec 19. - [Aβ-induced vulnerability propagates via the brain's default mode network.](https://pubmed.ncbi.nlm.nih.gov/31164641/#new_tab) - Pascoal TA, Mathotaarachchi S, Kang MS, Mohaddes S, Shin M, Park AY, Parent MJ, Benedet AL, Chamoun M, Therriault J, Hwang H, Cuello AC, Misic B, Soucy JP, Aston JAD, Gauthier S, Rosa-Neto P. Nat Commun. 2019 Jun 4;10(1):2353. doi: 10.1038/s41467-019-10217-w. - [Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.](https://pubmed.ncbi.nlm.nih.gov/30414086/#new_tab) - Schilling LP, Pascoal TA, Zimmer ER, Mathotaarachchi S, Shin M, de Mello Rieder CR, Gauthier S, Palmini A, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol Neurobiol. 2019 Jul;56(7):4916-4924. doi: 10.1007/s12035-018-1405-1. Epub 2018 Nov 9. - [Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals.](https://pubmed.ncbi.nlm.nih.gov/31673598/#new_tab) - Benedet AL, Ashton NJ, Pascoal TA, Leuzy A, Mathotaarachchi S, Kang MS, Therriault J, Savard M, Chamoun M, Schöll M, Zimmer ER, Gauthier S, Labbe A, Zetterberg H, Blennow K, Neto PR. Alzheimers Dement (Amst). 2019 Sep 27;11:679-689. doi: 10.1016/j.dadm.2019.08.002. eCollection 2019 Dec. - [Vascular retinal biomarkers improves the detection of the likely cerebral amyloid status from hyperspectral retinal images.](https://pubmed.ncbi.nlm.nih.gov/31650017/#new_tab) - Sharafi SM, Sylvestre JP, Chevrefils C, Soucy JP, Beaulieu S, Pascoal TA, Arbour JD, Rhéaume MA, Robillard A, Chayer C, Rosa-Neto P, Mathotaarachchi SS, Nasreddine ZS, Gauthier S, Lesage F. Alzheimers Dement (N Y). 2019 Oct 14;5:610-617. doi: 10.1016/j.trci.2019.09.006. eCollection 2019. - [Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum.](https://pubmed.ncbi.nlm.nih.gov/31230260/#new_tab) - Therriault J, Wang S, Mathotaarachchi S, Pascoal TA, Parent M, Beaudry T, Shin M, Al B, Kang MS, Ng KP, Dansereau C, Park MTM, Fonov V, Carbonell F, Zimmer E, Chakravarty MM, Bellec P, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol Neurobiol. 2019 Dec;56(12):8336-8344. doi: 10.1007/s12035-019-01671-0. Epub 2019 Jun 22. - [Suicidal ideation is common in autosomal dominant Alzheimer's disease at-risk persons.](https://pubmed.ncbi.nlm.nih.gov/31642105/#new_tab) - Ng KP, Richard-Devantoy S, Bertrand JA, Jiang L, Pascoal TA, Mathotaarachchi S, Therriault J, Yatawara C, Kandiah N, Greenwood CMT, Rosa-Neto P, Gauthier S; Dominantly Inherited Alzheimer Network. Int J Geriatr Psychiatry. 2020 Jan;35(1):60-68. doi: 10.1002/gps.5215. Epub 2019 Oct 22. - [Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.](https://pubmed.ncbi.nlm.nih.gov/31914223/#new_tab) - Lussier FZ, Pascoal TA, Chamoun M, Therriault J, Tissot C, Savard M, Kang MS, Mathotaarachchi S, Benedet AL, Parsons M, Qureshi MNI, Thomas ÉM, Shin M, Dion LA, Massarweh G, Soucy JP, Tsai IH, Vitali P, Ismail Z, Rosa-Neto P, Gauthier S. Alzheimers Dement. 2020 Jan;16(1):192-199. doi: 10.1002/alz.12007. - [Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.](https://pubmed.ncbi.nlm.nih.gov/31860000/#new_tab) - Therriault J, Benedet AL, Pascoal TA, Mathotaarachchi S, Chamoun M, Savard M, Thomas E, Kang MS, Lussier F, Tissot C, Parsons M, Qureshi MNI, Vitali P, Massarweh G, Soucy JP, Rej S, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. JAMA Neurol. 2020 Apr 1;77(4):470-479. doi: 10.1001/jamaneurol.2019.4421. - [Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.](https://pubmed.ncbi.nlm.nih.gov/32333900/#new_tab) - Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K. Lancet Neurol. 2020 May;19(5):422-433. doi: 10.1016/S1474-4422(20)30071-5. - [Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment.](https://pubmed.ncbi.nlm.nih.gov/32582834/#new_tab) - Pascoal TA, Therriault J, Mathotaarachchi S, Kang MS, Shin M, Benedet AL, Chamoun M, Tissot C, Lussier F, Mohaddes S, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement (Amst). 2020 Jun 21;12(1):e12037. doi: 10.1002/dad2.12037. eCollection 2020. - [18F-MK-6240 PET for early and late detection of neurofibrillary tangles.](https://pubmed.ncbi.nlm.nih.gov/32671408/#new_tab) - Pascoal TA, Therriault J, Benedet AL, Savard M, Lussier FZ, Chamoun M, Tissot C, Qureshi MNI, Kang MS, Mathotaarachchi S, Stevenson J, Hopewell R, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P. Brain. 2020 Sep 1;143(9):2818-2830. doi: 10.1093/brain/awaa180. - [Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.](https://pubmed.ncbi.nlm.nih.gov/33164988/#new_tab) - Favier M, Janickova H, Justo D, Kljakic O, Runtz L, Natsheh JY, Pascoal TA, Germann J, Gallino D, Kang JI, Meng XQ, Antinora C, Raulic S, Jacobsen JP, Moquin L, Vigneault E, Gratton A, Caron MG, Duriez P, Brandon MP, Neto PR, Chakravarty MM, Herzallah MM, Gorwood P, Prado MA, Prado VF, El Mestikawy S. - [Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/33210117/#new_tab) - Benedet AL, Leuzy A, Pascoal TA, Ashton NJ, Mathotaarachchi S, Savard M, Therriault J, Kang MS, Chamoun M, Schöll M, Zimmer ER, Gauthier S, Labbe A, Zetterberg H, Rosa-Neto P, Blennow K; Alzheimer’s Disease Neuroimaging Initiative. Brain. 2020 Dec 1;143(12):3793-3804. doi: 10.1093/brain/awaa342. - [Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging.](https://pubmed.ncbi.nlm.nih.gov/33264158/#new_tab) - Paquin V, Therriault J, Pascoal TA, Rosa-Neto P, Gauthier S. Cogn Behav Neurol. 2020 Dec;33(4):288-293. doi: 10.1097/WNN.0000000000000251. - [Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/33390174/#new_tab) - Ng KP, Pascoal TA, Mathotaarachchi S, Chan YH, Jiang L, Therriault J, Benedet AL, Shin M, Kandiah N, Greenwood CMT, Rosa-Neto P, Gauthier S; Dominantly Inherited Alzheimer Network. Transl Neurodegener. 2021 Jan 4;10(1):1. doi: 10.1186/s40035-020-00225-y. - [Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease.](https://pubmed.ncbi.nlm.nih.gov/33093220/#new_tab) - Therriault J, Pascoal TA, Savard M, Benedet AL, Chamoun M, Tissot C, Lussier F, Kang MS, Thomas E, Terada T, Rej S, Massarweh G, Nasreddine Z, Vitali P, Soucy JP, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. Neurology. 2021 Jan 5;96(1):e81-e92. doi: 10.1212/WNL.0000000000011081. Epub 2020 Oct 22. - [Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.](https://pubmed.ncbi.nlm.nih.gov/33106600/#new_tab) - Karikari TK, Benedet AL, Ashton NJ, Lantero Rodriguez J, Snellman A, Suárez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schöll M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K, Zetterberg H; Alzheimer’s Disease Neuroimaging Initiative. Mol Psychiatry. 2021 Feb;26(2):429-442. doi: 10.1038/s41380-020-00923-z. Epub 2020 Oct 26. - [Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging.](https://pubmed.ncbi.nlm.nih.gov/32737243/#new_tab) - Therriault J, Benedet AL, Pascoal TA, Savard M, Ashton NJ, Chamoun M, Tissot C, Lussier F, Kang MS, Bezgin G, Wang T, Fernandes-Arias J, Massarweh G, Vitali P, Zetterberg H, Blennow K, Saha-Chaudhuri P, Soucy JP, Gauthier S, Rosa-Neto P. J Nucl Med. 2021 Feb;62(2):247-252. doi: 10.2967/jnumed.120.245209. Epub 2020 Jul 31. - [Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment.](https://pubmed.ncbi.nlm.nih.gov/33443136/#new_tab) - Therriault J, Pascoal TA, Benedet AL, Tissot C, Savard M, Chamoun M, Lussier F, Kang MS, Berzgin G, Wang T, Fernandes-Arias J, Massarweh G, Soucy JP, Vitali P, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. Neurology. 2021 Feb 16;96(7):e975-e985. doi: 10.1212/WNL.0000000000011416. Epub 2020 Dec 21. - [Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/33781319/#new_tab) - Tissot C, L Benedet A, Therriault J, Pascoal TA, Lussier FZ, Saha-Chaudhuri P, Chamoun M, Savard M, Mathotaarachchi SS, Bezgin G, Wang YT, Fernandez Arias J, Rodriguez JL, Snellman A, Ashton NJ, Karikari TK, Blennow K, Zetterberg H, De Villers-Sidani E, Huot P, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Res Ther. 2021 - [Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/33816761/#new_tab) - Tissot C, Therriault J, Pascoal TA, Chamoun M, Lussier FZ, Savard M, Mathotaarachchi SS, L Benedet A, Thomas EM, Parsons M, Nasreddine Z, Rosa-Neto P, Gauthier S. Alzheimers Dement (N Y). 2021 Mar 31;7(1):e12154. doi: 10.1002/trc2.12154. eCollection 2021. - [Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals.](https://pubmed.ncbi.nlm.nih.gov/33959711/#new_tab) - Lussier FZ, Benedet AL, Therriault J, Pascoal TA, Tissot C, Chamoun M, Mathotaarachchi S, Savard M, Ashton NJ, Karikari TK, Rodriguez JL, Snellman A, Bezgin G, Kang MS, Fernandez Arias J, Wang YT, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Brain Commun. 2021 Apr 15;3(2):fcab073. doi: 10.1093/braincomms/fcab073. eCollection 2021. - [Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/33902654/#new_tab) - Terada T, Therriault J, Kang MSP, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P. Mol Neurodegener. 2021 Apr 26;16(1):28. doi: 10.1186/s13024-021-00448-1. - [Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/33911072/#new_tab) - Lyra E Silva NM, Gonçalves RA, Pascoal TA, Lima-Filho RAS, Resende EPF, Vieira ELM, Teixeira AL, de Souza LC, Peny JA, Fortuna JTS, Furigo IC, Hashiguchi D, Miya-Coreixas VS, Clarke JR, Abisambra JF, Longo BM, Donato J Jr, Fraser PE, Rosa-Neto P, Caramelli P, Ferreira ST, De Felice FG. Transl Psychiatry. 2021 Apr 28;11(1):251. doi: - [Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology.](https://pubmed.ncbi.nlm.nih.gov/33585983/#new_tab) - Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, Snellman A, Schöll M, Troakes C, Hye A, Gauthier S, Vanmechelen E, Zetterberg H, Rosa-Neto P, Blennow K. Acta Neuropathol. 2021 May;141(5):709-724. doi: 10.1007/s00401-021-02275-6. Epub 2021 Feb 14. - [What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.](https://pubmed.ncbi.nlm.nih.gov/33384320/#new_tab) - Villemagne VL, Lopresti BJ, Doré V, Tudorascu D, Ikonomovic MD, Burnham S, Minhas D, Pascoal TA, Mason NS, Snitz B, Aizenstein H, Mathis CA, Lopez O, Rowe CC, Klunk WE, Cohen AD. J Nucl Med. 2021 May 10;62(5):614-619. doi: 10.2967/jnumed.120.245423. Epub 2020 Dec 31. - [A multicentre validation study of the diagnostic value of plasma neurofilament light.](https://pubmed.ncbi.nlm.nih.gov/34099648/#new_tab) - Ashton NJ, Janelidze S, Al Khleifat A, Leuzy A, van der Ende EL, Karikari TK, Benedet AL, Pascoal TA, Lleó A, Parnetti L, Galimberti D, Bonanni L, Pilotto A, Padovani A, Lycke J, Novakova L, Axelsson M, Velayudhan L, Rabinovici GD, Miller B, Pariante C, Nikkheslat N, Resnick SM, Thambisetty M, Schöll M, Fernández-Eulate G, - [Interactive rather than independent effect of APOE and sex potentiates tau deposition in women.](https://pubmed.ncbi.nlm.nih.gov/34189460/#new_tab) - Wang YT, Pascoal TA, Therriault J, Kang MS, Benedet AL, Savard M, Tissot C, Lussier FZ, Arias JF, Mathotaarachchi S, Rajah MN, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Brain Commun. 2021 Jun 7;3(2):fcab126. doi: 10.1093/braincomms/fcab126. eCollection 2021. - [Association of plasma P-tau181 with memory decline in non-demented adults.](https://pubmed.ncbi.nlm.nih.gov/34222875/#new_tab) - Therriault J, Benedet AL, Pascoal TA, Lussier FZ, Tissot C, Karikari TK, Ashton NJ, Chamoun M, Bezgin G, Mathotaarachchi S, Gauthier S, Saha-Chaudhuri P, Zetterberg H, Blennow K, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Brain Commun. 2021 Jun 14;3(3):fcab136. doi: 10.1093/braincomms/fcab136. eCollection 2021 Jul. - [A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis.](https://pubmed.ncbi.nlm.nih.gov/34041562/#new_tab) - Leuzy A, Pascoal TA, Strandberg O, Insel P, Smith R, Mattsson-Carlgren N, Benedet AL, Cho H, Lyoo CH, La Joie R, Rabinovici GD, Ossenkoppele R, Rosa-Neto P, Hansson O. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2295-2305. doi: 10.1007/s00259-021-05401-4. Epub 2021 May 27. - [Microglial activation and tau propagate jointly across Braak stages.](https://pubmed.ncbi.nlm.nih.gov/34446931/#new_tab) - Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26. - [APOEε4 potentiates the relationship between amyloid-β and tau pathologies.](https://pubmed.ncbi.nlm.nih.gov/32161362/#new_tab) - Therriault J, Benedet AL, Pascoal TA, Mathotaarachchi S, Savard M, Chamoun M, Thomas E, Kang MS, Lussier F, Tissot C, Soucy JP, Massarweh G, Rej S, Saha-Chaudhuri P, Poirier J, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol Psychiatry. 2021 Oct;26(10):5977-5988. doi: 10.1038/s41380-020-0688-6. Epub 2020 Mar 11. - [Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia.](https://pubmed.ncbi.nlm.nih.gov/34617688/#new_tab) - Therriault J, Pascoal TA, Sefranek M, Mathotaarachchi S, Benedet AL, Chamoun M, Lussier FZ, Tissot C, Bellaver B, Lukasewicz PS, Zimmer ER, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Ann Clin Transl Neurol. 2021 Oct;8(10):2083-2092. doi: 10.1002/acn3.51457. Epub 2021 Oct 7. - [Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/32591633/#new_tab) - Kang MS, Aliaga AA, Shin M, Mathotaarachchi S, Benedet AL, Pascoal TA, Therriault J, Chamoun M, Savard M, Devenyi GA, Mathieu A, Chakravarty MM, Sandelius Å, Blennow K, Zetterberg H, Soucy JP, Cuello AC, Massarweh G, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol Psychiatry. 2021 Oct;26(10):5989-6001. doi: 10.1038/s41380-020-0818-1. Epub 2020 Jun 26. - [Publisher Correction: Microglial activation and tau propagate jointly across Braak stages.](https://pubmed.ncbi.nlm.nih.gov/34654920/#new_tab) - Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Nat Med. 2021 Nov;27(11):2048-2049. doi: 10.1038/s41591-021-01568-3. - [Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid.](https://pubmed.ncbi.nlm.nih.gov/34773730/#new_tab) - Gobom J, Parnetti L, Rosa-Neto P, Vyhnalek M, Gauthier S, Cataldi S, Lerch O, Laczo J, Cechova K, Clarin M, Benet AL, Pascoal TA, Rahmouni N, Vandijck M, Huyck E, Le Bastard N, Stevenson J, Chamoun M, Alcolea D, Lleó A, Andreasson U, Verbeek MM, Bellomo G, Rinaldi R, Ashton NJ, Zetterberg H, Sheardova K, - [Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum.](https://pubmed.ncbi.nlm.nih.gov/34661615/#new_tab) - Benedet AL, Milà-Alomà M, Vrillon A, Ashton NJ, Pascoal TA, Lussier F, Karikari TK, Hourregue C, Cognat E, Dumurgier J, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Salvadó G, Shekari M, Operto G, Gispert JD, Minguillon C, Fauria K, Kollmorgen G, Suridjan I, Zimmer ER, Zetterberg H, Molinuevo JL, Paquet C, Rosa-Neto P, Blennow - [Soluble amyloid-beta isoforms predict downstream Alzheimer's disease pathology.](https://pubmed.ncbi.nlm.nih.gov/34895338/#new_tab) - Povala G, Bellaver B, De Bastiani MA, Brum WS, Ferreira PCL, Bieger A, Pascoal TA, Benedet AL, Souza DO, Araujo RM, Zatt B, Rosa-Neto P, Zimmer ER; for the Alzheimer’s Disease Neuroimaging Initiative. Cell Biosci. 2021 Dec 11;11(1):204. doi: 10.1186/s13578-021-00712-3. - [Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.](https://pubmed.ncbi.nlm.nih.gov/34515754/#new_tab) - Pascoal TA, Benedet AL, Tudorascu DL, Therriault J, Mathotaarachchi S, Savard M, Lussier FZ, Tissot C, Chamoun M, Kang MS, Stevenson J, Massarweh G, Guiot MC, Soucy JP, Gauthier S, Rosa-Neto P. Brain. 2021 Dec 16;144(11):3517-3528. doi: 10.1093/brain/awab248. - [Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects.](https://pubmed.ncbi.nlm.nih.gov/33863821/#new_tab) - Gogola A, Minhas DS, Villemagne VL, Cohen AD, Mountz JM, Pascoal TA, Laymon CM, Mason NS, Ikonomovic MD, Mathis CA, Snitz BE, Lopez OL, Klunk WE, Lopresti BJ. J Nucl Med. 2022 Jan;63(1):108-116. doi: 10.2967/jnumed.120.254961. Epub 2021 Apr 16. - [Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia.](https://pubmed.ncbi.nlm.nih.gov/35073256/#new_tab) - Savard M, Pascoal TA, Servaes S, Dhollander T, Iturria-Medina Y, Kang MS, Vitali P, Therriault J, Mathotaarachchi S, Benedet AL, Gauthier S, Rosa-Neto P; Frontotemporal Lobar Degeneration Neuroimaging Initiative. Elife. 2022 Jan 24;11:e73510. doi: 10.7554/eLife.73510. - [Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET.](https://pubmed.ncbi.nlm.nih.gov/35134647/#new_tab) - Tissot C, Therriault J, Kunach P, L Benedet A, Pascoal TA, Ashton NJ, Karikari TK, Servaes S, Lussier FZ, Chamoun M, Tudorascu DL, Stevenson J, Rahmouni N, Poltronetti NM, Pallen V, Bezgin G, Kang MS, Mathotaarachchi SS, Wang YT, Fernandez Arias J, Ferreira PCL, Ferrari-Souza JP, Vanmechelen E, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto - [Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35158308/#new_tab) - Ashton NJ, Benedet AL, Pascoal TA, Karikari TK, Lantero-Rodriguez J, Brum WS, Mathotaarachchi S, Therriault J, Savard M, Chamoun M, Stoops E, Francois C, Vanmechelen E, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Rosa-Neto P. EBioMedicine. 2022 Feb;76:103836. doi: 10.1016/j.ebiom.2022.103836. Epub 2022 Feb 12. - [A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35310530/#new_tab) - Brum WS, de Bastiani MA, Bieger A, Therriault J, Ferrari-Souza JP, Benedet AL, Saha-Chaudhuri P, Souza DO, Ashton NJ, Zetterberg H, Pascoal TA, Karikari T, Blennow K, Rosa-Neto P, Zimmer ER; Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimers Dement (N Y). 2022 Mar 13;8(1):e12270. doi: 10.1002/trc2.12270. eCollection 2022. - [Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35177805/#new_tab) - Cassidy CM, Therriault J, Pascoal TA, Cheung V, Savard M, Tuominen L, Chamoun M, McCall A, Celebi S, Lussier F, Massarweh G, Soucy JP, Weinshenker D, Tardif C, Ismail Z, Gauthier S, Rosa-Neto P. Neuropsychopharmacology. 2022 Apr;47(5):1128-1136. doi: 10.1038/s41386-022-01293-6. Epub 2022 Feb 17. - [Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35007366/#new_tab) - Terada T, Therriault J, Kang MS, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Poltronetti NM, Ottoy J, Arias JF, Bezgin G, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P. Eur J Neurol. 2022 May;29(5):1324-1334. doi: 10.1111/ene.15246. Epub 2022 Jan 22. - [Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.](https://pubmed.ncbi.nlm.nih.gov/34378436/#new_tab) - Kang MS, Shin M, Ottoy J, Aliaga AA, Mathotaarachchi S, Quispialaya K, Pascoal TA, Collins DL, Chakravarty MM, Mathieu A, Sandelius Å, Blennow K, Zetterberg H, Massarweh G, Soucy JP, Cuello AC, Gauthier S, Waterston M, Yoganathan N, Lessard E, Haqqani A, Rennie K, Stanimirovic D, Chakravarthy B, Rosa-Neto P. J Cereb Blood Flow Metab. - [18F-MK-6240 tau-PET in genetic frontotemporal dementia.](https://pubmed.ncbi.nlm.nih.gov/34664612/#new_tab) - Levy JP, Bezgin G, Savard M, Pascoal TA, Finger E, Laforce R, Sonnen JA, Soucy JP, Gauthier S, Rosa-Neto P, Ducharme S. Brain. 2022 Jun 3;145(5):1763-1772. doi: 10.1093/brain/awab392. - [Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35659284/#new_tab) - Nilsson J, Ashton NJ, Benedet AL, Montoliu-Gaya L, Gobom J, Pascoal TA, Chamoun M, Portelius E, Jeromin A, Mendes M, Zetterberg H, Rosa-Neto P, Brinkmalm A, Blennow K. Alzheimers Res Ther. 2022 Jun 4;14(1):78. doi: 10.1186/s13195-022-01021-8. - [Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility.](https://pubmed.ncbi.nlm.nih.gov/35585226/#new_tab) - Karikari TK, Ashton NJ, Brinkmalm G, Brum WS, Benedet AL, Montoliu-Gaya L, Lantero-Rodriguez J, Pascoal TA, Suárez-Calvet M, Rosa-Neto P, Blennow K, Zetterberg H. Nat Rev Neurol. 2022 Jul;18(7):400-418. doi: 10.1038/s41582-022-00665-2. Epub 2022 May 18. - [[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35853847/#new_tab) - Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh - [Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/35948658/#new_tab) - Ferrari-Souza JP, Ferreira PCL, Bellaver B, Tissot C, Wang YT, Leffa DT, Brum WS, Benedet AL, Ashton NJ, De Bastiani MA, Rocha A, Therriault J, Lussier FZ, Chamoun M, Servaes S, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Klunk WE, Tudorascu DL, Cohen AD, Villemagne VL, Gauthier S, Blennow K, - [Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases".](https://pubmed.ncbi.nlm.nih.gov/36001681/#new_tab) - Zimmer ER, Pascoal TA, Rosa-Neto P, Nordberg A, Pellerin L. Sci Transl Med. 2022 Aug 24;14(659):eabm8302. doi: 10.1126/scitranslmed.abm8302. Epub 2022 Aug 24. - [Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/36001678/#new_tab) - Therriault J, Pascoal TA, Savard M, Mathotaarachchi S, Benedet AL, Chamoun M, Tissot C, Lussier FZ, Rahmouni N, Stevenson J, Qureshi MNI, Kang MS, Thomas É, Vitali P, Soucy JP, Massarweh G, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. Sci Transl Med. 2022 Aug 24;14(659):eabc8693. doi: 10.1126/scitranslmed.abc8693. Epub 2022 Aug 24. - [Staging of Alzheimer's disease: past, present, and future perspectives.](https://pubmed.ncbi.nlm.nih.gov/35717526/#new_tab) - Therriault J, Zimmer ER, Benedet AL, Pascoal TA, Gauthier S, Rosa-Neto P. Trends Mol Med. 2022 Sep;28(9):726-741. doi: 10.1016/j.molmed.2022.05.008. Epub 2022 Jun 15. - [Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.](https://pubmed.ncbi.nlm.nih.gov/36192402/#new_tab) - Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh - [Subjective cognitive decline in Brazil: Prevalence and association with dementia modifiable risk factors in a population-based study.](https://pubmed.ncbi.nlm.nih.gov/36398001/#new_tab) - Borelli WV, Zimmer ER, Bieger A, Coelho B, Pascoal TA, Chaves MLF, Amariglio R, Castilhos RM. Alzheimers Dement (Amst). 2022 Nov 14;14(1):e12368. doi: 10.1002/dad2.12368. eCollection 2022. - [Endocannabinoid System Biomarkers in Alzheimer's Disease.](https://pubmed.ncbi.nlm.nih.gov/36394442/#new_tab) - Ferreira PCL, Bellaver B, Povala G, Brum WS, Tissot C, Badji A, Sloan ME, Benedet AL, Rosa-Neto P, Ashton NJ, Pascoal TA, Leuzy A, Zimmer ER. Cannabis Cannabinoid Res. 2022 Nov 17. doi: 10.1089/can.2022.0151. Online ahead of print. - [The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau-PET in target regions.](https://pubmed.ncbi.nlm.nih.gov/36396455/#new_tab) - Tissot C, Servaes S, Lussier FZ, Ferrari-Souza JP, Therriault J, Ferreira PCL, Bezgin G, Bellaver B, Teixeira Leffa D, Mathotaarachchi SS, Chamoun M, Stevenson J, Rahmouni N, Kang MS, Pallen V, Poltronetti NM, Wang YT, Fernandez-Arias J, Benedet AL, Zimmer ER, Soucy JP, Tudorascu DL, Cohen AD, Sharp M, Gauthier S, Massarweh G, Lopresti BJ, - [Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older adults.](https://pubmed.ncbi.nlm.nih.gov/36476732/#new_tab) - Leffa DT, Ferrari-Souza JP, Bellaver B, Tissot C, Ferreira PCL, Brum WS, Caye A, Lord J, Proitsi P, Martins-Silva T, Tovo-Rodrigues L, Tudorascu DL, Villemagne VL, Cohen AD, Lopez OL, Klunk WE, Karikari TK, Rosa-Neto P, Zimmer ER, Molina BSG, Rohde LA, Pascoal TA; Alzheimer’s Disease Neuroimaging Initiative. Mol Psychiatry. 2022 Dec 8. doi: 10.1038/s41380-022-01867-2. - [Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease.](https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/dad2.12390#new_tab) - Tharick A. Pascoal, Antoine Leuzy, Joseph Therriault, Mira Chamoun, Firoza Lussier, Cecile Tissot, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Ruben Smith, Andrea Lessa Benedet, Serge Gauthier, Oskar Hansson, Pedro Rosa-Neto. Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringVolume 15, Issue 1 Jan 2023. - [Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12986#.ZAYXbylGpxM.twitter#new_tab) - Pamela C. L. Ferreira, Yingjin Zhang, Beth Snitz, Chung-Chou H. Chang, Bruna Bellaver, Erin Jacobsen, M. Ilyas Kamboh, Henrik Zetterberg, Kaj Blennow, Tharick A. Pascoal, Victor L. Villemagne, Mary Ganguli, Thomas K. Karikari. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://doi.org/10.1002/alz.12986 ## Categories - [Publication](https://pascoallab.org/category/publication/) - [News](https://pascoallab.org/category/news/)