Welcome to the
Pascoal Lab
About the
Lab
Our lab is interested in the quantification of brain pathophysiology in patients with Alzheimer’s disease (AD) and related dementias as well as in the validation of therapies capable of modifying the course of these diseases producing an enduring disease-modifying and clinically relevant effect. This involves the validation of positron emission tomography (PET) and fluid biomarker techniques capable of measuring these brain pathologies and monitoring their progression.
Research in
Focus
Recent
Publications
JAMA Network
Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease
Nature Aging
APOEε4 potentiates amyloid β effects on longitudinal tau pathology
Alzheimer’s & Dementia
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
Nature Medicine
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Science Advances
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
Alzheimer’s & Dementia
Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology
Stay Tuned
News
Funding
Affiliations
Funding
Affiliations