Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
Pamela C. L. Ferreira, Joseph Therriault, Cécile Tissot, João Pedro Ferrari-Souza, Andréa L. Benedet, Guilherme Povala, Bruna Bellaver, Douglas T. Leffa, Wagner S. Brum, Firoza Z. Lussier, Gleb Bezgin, Stijn Servaes, Marie Vermeiren, Arthur C. Macedo, Arlec Cabrera, Jenna Stevenson, Gallen Triana-Baltzer, Hartmuth Kolb, Nesrine Rahmouni, William E. Klunk, Oscar L. Lopez, Victor L. Villemagne, Ann Cohen, Dana L. Tudorascu, Eduardo R. Zimmer, Thomas K. Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto, Tharick A. Pascoal
Alzheimer’s & Dementia
The GABAergic system in Alzheimer’s disease: a systematic review with meta-analysis
Giovanna Carello-Collar, Bruna Bellaver, Pamela C L Ferreira, João Pedro Ferrari-Souza, Vanessa G Ramos, Joseph Therriault, Cécile Tissot, Marco A De Bastiani, Carolina Soares, Tharick A Pascoal, Pedro Rosa-Neto, Diogo O Souza, Eduardo R Zimmer
Mol Psychiatry. 2023
The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework
Arthur C Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R Zimmer, Marie-Christine Guiot, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Neto
J Nucl Med. 2023
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies
Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blennow
Nat Aging. 2023
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Andréa L. Benedet, Nicholas J. Ashton, Gallen Triana-Baltzer, Hartmuth C. Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L. Lopez, Dana L. Tudorascu, Victor L. Villemagne, Milos D. Ikonomovic, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Howard J. Aizenstein, William E. Klunk, Beth E. Snitz, Pauline Maki, Rebecca C. Thurston, Ann D. Cohen, Mary Ganguli, Thomas K. Karikari, Pedro Rosa-Neto & Tharick A. Pascoal
Nature Medicine (2023)
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
João Pedro Ferrari-Souza, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela C. L. Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L. Benedet, Nicholas J. Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, JennaStevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T. O’Brien, James B. Rowe, Ann D. Cohen, Oscar L. Lopez, Dana L. Tudorascu, Thomas K. Karikari, William E. Klunk, Victor L. Villemagne, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto,Tharick A. Pascoal
Science Advances, 5 Apr 2023, Vol 9, Issue 14
DOI: 10.1126/sciadv.ade1474
Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology
Bruna Bellaver, Albert Puig-Pijoan, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cécile Tissot, Guilherme Povala, Joseph Therriault, Andréa L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suárez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal.
Alzheimer’s & Dementia 15 March 2023 https://doi.org/10.1002/alz.13014
Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies
Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G. Souza, Pamela C.L. Ferreira, Andreia S. Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L. Benedet, Nicholas J. Ashton, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A. Pascoal, Eduardo R. Zimmer, for the Alzheimer’s Disease Neuroimaging Initiative
Brain Behavior and Immunity May 2023 doi.org/10.1016/j.bbi.2023.03.001
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials
Pamela Ferreira, João Pedro Ferrari-Souza, Cécile Tissot, Bruna Bellaver, Douglas Leffa, Firoza Lussier,Guilherme Povala, Joseph Therriault, Andréa L Benedet, Nicholas J Ashton, Ann D. Cohen, Oscar L. Lopez, Dana Tudorascu, William E. Klunk, Jean-Paul Soucy, Serge Gauthier, Victor Villemagne, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Eduardo R. Zimmer, Thomas K Karikari, Tharick Pascoal, for the Alzheimer’s Disease Neuroimaging Initiative
Neurology
DOI: 10.1212/WNL.0000000000207115