APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
João Pedro Ferrari-Souza, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela C. L. Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L. Benedet, Nicholas J. Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, JennaStevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T. O’Brien, James B. Rowe, Ann D. Cohen, Oscar L. Lopez, Dana L. Tudorascu, Thomas K. Karikari, William E. Klunk, Victor L. Villemagne, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto,Tharick A. Pascoal
SCIENCE ADVANCES, 5 Apr 2023, Vol 9, Issue 14
DOI: 10.1126/sciadv.ade1474
Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology
Bruna Bellaver, Albert Puig-Pijoan, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cécile Tissot, Guilherme Povala, Joseph Therriault, Andréa L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suárez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal.
Alzheimer’s & Dementia 15 March 2023 https://doi.org/10.1002/alz.13014
Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies
Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G. Souza, Pamela C.L. Ferreira, Andreia S. Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L. Benedet, Nicholas J. Ashton, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A. Pascoal, Eduardo R. Zimmer, for the Alzheimer’s Disease Neuroimaging Initiative
Brain Behavior and Immunity May 2023 doi.org/10.1016/j.bbi.2023.03.001
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials
Pamela Ferreira, João Pedro Ferrari-Souza, Cécile Tissot, Bruna Bellaver, Douglas Leffa, Firoza Lussier,Guilherme Povala, Joseph Therriault, Andréa L Benedet, Nicholas J Ashton, Ann D. Cohen, Oscar L. Lopez, Dana Tudorascu, William E. Klunk, Jean-Paul Soucy, Serge Gauthier, Victor Villemagne, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Eduardo R. Zimmer, Thomas K Karikari, Tharick Pascoal, for the Alzheimer’s Disease Neuroimaging Initiative
Neurology
DOI: 10.1212/WNL.0000000000207115
Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population-based cohort
Pamela C. L. Ferreira, Yingjin Zhang, Beth Snitz, Chung-Chou H. Chang, Bruna Bellaver, Erin Jacobsen, M. Ilyas Kamboh, Henrik Zetterberg, Kaj Blennow, Tharick A. Pascoal, Victor L. Villemagne, Mary Ganguli, Thomas K. Karikari.
Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. https://doi.org/10.1002/alz.12986
Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer’s disease.
Tharick A. Pascoal, Antoine Leuzy, Joseph Therriault, Mira Chamoun, Firoza Lussier, Cecile Tissot, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Ruben Smith, Andrea Lessa Benedet, Serge Gauthier, Oskar Hansson, Pedro Rosa-Neto.
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringVolume 15, Issue 1 Jan 2023.
Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults.
Leffa DT, Ferrari-Souza JP, Bellaver B, Tissot C, Ferreira PCL, Brum WS, Caye A, Lord J, Proitsi P, Martins-Silva T, Tovo-Rodrigues L, Tudorascu DL, Villemagne VL, Cohen AD, Lopez OL, Klunk WE, Karikari TK, Rosa-Neto P, Zimmer ER, Molina BSG, Rohde LA, Pascoal TA; Alzheimer’s Disease Neuroimaging Initiative.
Mol Psychiatry. 2022 Dec 8. doi: 10.1038/s41380-022-01867-2. Online ahead of print.
The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau-PET in target regions.
Tissot C, Servaes S, Lussier FZ, Ferrari-Souza JP, Therriault J, Ferreira PCL, Bezgin G, Bellaver B, Teixeira Leffa D, Mathotaarachchi SS, Chamoun M, Stevenson J, Rahmouni N, Kang MS, Pallen V, Poltronetti NM, Wang YT, Fernandez-Arias J, Benedet AL, Zimmer ER, Soucy JP, Tudorascu DL, Cohen AD, Sharp M, Gauthier S, Massarweh G, Lopresti BJ, Klunk WE, Baker SL, Villemagne VL, Rosa-Neto P, Pascoal TA.
J Nucl Med. 2022 Nov 17:jnumed.122.264434. doi: 10.2967/jnumed.122.264434. Online ahead of print.
Endocannabinoid System Biomarkers in Alzheimer’s Disease.
Ferreira PCL, Bellaver B, Povala G, Brum WS, Tissot C, Badji A, Sloan ME, Benedet AL, Rosa-Neto P, Ashton NJ, Pascoal TA, Leuzy A, Zimmer ER.
Cannabis Cannabinoid Res. 2022 Nov 17. doi: 10.1089/can.2022.0151. Online ahead of print.