Welcome to the

Pascoal Lab

About the

Lab

Our lab is interested in the quantification of brain pathophysiology in patients with Alzheimer’s disease (AD) and related dementias as well as in the validation of therapies capable of modifying the course of these diseases producing an enduring disease-modifying and clinically relevant effect. This involves the validation of positron emission tomography (PET) and fluid biomarker techniques capable of measuring these brain pathologies and monitoring their progression.

Recent

Publications

Science Advances

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles

Alzheimer’s & Dementia

Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology

Brain Behavior and Immunity

Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies

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Funding

Affiliations

Funding

Affiliations