About us

Our lab is interested in the quantification of brain pathophysiology in patients with Alzheimer’s disease (AD) and related dementias as well as in the validation of therapies capable of modifying the course of these diseases producing an enduring disease-modifying and clinically relevant effect. This involves the validation of positron emission tomography (PET) and fluid biomarker techniques capable of measuring these brain pathologies and monitoring their progression.

Recent Publications

Mol Psychiatry

Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults

Cannabis Cannabinoid Res

Endocannabinoid System Biomarkers in Alzheimer’s Disease

J Nucl Med

The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau-PET in target regions

Alzheimers Dement

Subjective cognitive decline in Brazil: Prevalence and association with dementia modifiable risk factors in a population-based study

Trends Mol Med

Staging of Alzheimer’s disease: past, present, and future perspectives

Sci Transl Med

Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer’s disease

Stay Tuned

@dtleffa, from the @LabPascoal, found that genetic liability for ADHD is associated with cognitive decline and the development of #alzheimers pathophysiology https://www.nature.com/articles/s41380-022-01867-2 14/+

In a work led by @CecileTss from @LabPascoal and @Imaging_AD labs we evaluated the effects of age-related and off-target retention on the longitudinal quantification of the tau tracer [18F]MK6240. https://jnm.snmjournals.org/content/early/2022/11/17/jnumed.122.264434.long 12/+

@jpfsouza33 @TharickAPascoal @LabPascoal et al. showed the existence of distinct astrocyte biomarker signatures in response to brain Aβ and tau accumulation, which may contribute to our understanding of the reactive astrogliosis heterogeneity in AD 👉 https://www.nature.com/articles/s41380-022-01716-2 4/+

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