Welcome to the

Pascoal Lab

About the


Our lab is interested in the quantification of brain pathophysiology in patients with Alzheimer’s disease (AD) and related dementias as well as in the validation of therapies capable of modifying the course of these diseases producing an enduring disease-modifying and clinically relevant effect. This involves the validation of positron emission tomography (PET) and fluid biomarker techniques capable of measuring these brain pathologies and monitoring their progression.

Research in




JAMA Network

Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Nature Aging

APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Alzheimer’s & Dementia

Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals

Nature Medicine

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Science Advances

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles

Alzheimer’s & Dementia

Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology