In Alzheimer’s disease, reactive astrocytes can play an important role in the pathophysiology of the disease. Amyloid-β and tau tangles—the two main pathological hallmarks of Alzheimer’s disease—are associated with astrocyte reactivity. However, knowledge about...
The National Institute on Aging (NIA) has awarded the University of Pittsburgh Department of Psychiatry a Program Project Grant (PPG) renewal for “The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer’s disease.” The...
PITTSBURGH – Contrary to early studies, brain levels of enzymes that regulate DNA-folding drop as Alzheimer’s disease progresses, neuroscientists from the University of Pittsburgh, McGill University and Harvard University reported...
In fall 2021, Alzheimer’s Disease International published World Alzheimer Report 2021: Journey though the diagnosis of dementia, a compendium of research on the disease, currently the seventh leading cause of mortality worldwide. The report addresses numerous...
Investigators including Pitt Psychiatry’s Tharick Pascoal, MD, PhD (Assistant Professor of Psychiatry and Neurology), have published a paper in Nature Medicine investigating the correlation between microglial activation, abnormal tau tangles (a...
