Publications

Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies

Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blennow

Nat Aging. 2023

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Andréa L. Benedet, Nicholas J. Ashton, Gallen Triana-Baltzer, Hartmuth C. Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L. Lopez, Dana L. Tudorascu, Victor L. Villemagne, Milos D. Ikonomovic, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Howard J. Aizenstein, William E. Klunk, Beth E. Snitz, Pauline Maki, Rebecca C. Thurston, Ann D. Cohen, Mary Ganguli, Thomas K. Karikari, Pedro Rosa-Neto & Tharick A. Pascoal

Nature Medicine (2023)

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles

João Pedro Ferrari-Souza, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela C. L. Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L. Benedet, Nicholas J. Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, JennaStevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T. O’Brien, James B. Rowe, Ann D. Cohen, Oscar L. Lopez, Dana L. Tudorascu, Thomas K. Karikari, William E. Klunk, Victor L. Villemagne, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto,Tharick A. Pascoal

Science Advances, 5 Apr 2023, Vol 9, Issue 14
DOI: 10.1126/sciadv.ade1474

Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology

Bruna Bellaver, Albert Puig-Pijoan, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cécile Tissot, Guilherme Povala, Joseph Therriault, Andréa L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suárez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal.

Alzheimer’s & Dementia 15 March 2023 https://doi.org/10.1002/alz.13014 

Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies

Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G. Souza, Pamela C.L. Ferreira, Andreia S. Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L. Benedet, Nicholas J. Ashton, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A. Pascoal, Eduardo R. Zimmer, for the Alzheimer’s Disease Neuroimaging Initiative

Brain Behavior and Immunity May 2023 doi.org/10.1016/j.bbi.2023.03.001

Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials

Pamela Ferreira,  João Pedro Ferrari-Souza, Cécile Tissot, Bruna Bellaver, Douglas Leffa, Firoza Lussier,Guilherme Povala, Joseph Therriault, Andréa L Benedet, Nicholas J Ashton, Ann D. Cohen, Oscar L. Lopez, Dana Tudorascu, William E. Klunk, Jean-Paul Soucy, Serge Gauthier, Victor Villemagne, Henrik Zetterberg,  Kaj Blennow, Pedro Rosa-Neto, Eduardo R. Zimmer, Thomas K Karikari, Tharick Pascoal, for the Alzheimer’s Disease Neuroimaging Initiative

Neurology
DOI: 10.1212/WNL.0000000000207115

Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population-based cohort

Pamela C. L. Ferreira, Yingjin Zhang, Beth Snitz, Chung-Chou H. Chang, Bruna Bellaver, Erin Jacobsen, M. Ilyas Kamboh, Henrik Zetterberg, Kaj Blennow, Tharick A. Pascoal, Victor L. Villemagne, Mary Ganguli, Thomas K. Karikari.

Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. https://doi.org/10.1002/alz.12986

Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults.

Leffa DT, Ferrari-Souza JP, Bellaver B, Tissot C, Ferreira PCL, Brum WS, Caye A, Lord J, Proitsi P, Martins-Silva T, Tovo-Rodrigues L, Tudorascu DL, Villemagne VL, Cohen AD, Lopez OL, Klunk WE, Karikari TK, Rosa-Neto P, Zimmer ER, Molina BSG, Rohde LA, Pascoal TA; Alzheimer’s Disease Neuroimaging Initiative.

Mol Psychiatry. 2022 Dec 8. doi: 10.1038/s41380-022-01867-2. Online ahead of print.