Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease
Cristiano Schaffer Aguzzoli, MD; Pâmela C. L. Ferreira, PhD; Guilherme Povala, PhD; João Pedro Ferrari-Souza; Bruna Bellaver, PhD; Carolina Soares Katz, MSc; Hussein Zalzale, MSc; Firoza Z. Lussier, MSc; Francieli Rohden, PhD; Sarah Abbas, MD; Douglas T. Leffa, PhD; Marina Scop Medeiros, MD; Joseph Therriault, PhD; Andréa L. Benedet, PhD; Cécile Tissot, PhD; Stijn Servaes, PhD; Nesrine Rahmouni, BSc; Arthur Cassa Macedo, MD; Gleb Bezgin, PhD; Min Su Kang, PhD;
Jenna Stevenson, BSc; Vanessa Pallen, BA; Ann Cohen, PhD; Oscar L. Lopez, MD; Dana L. Tudorascu, PhD; William E. Klunk, PhD; Victor L. Villemagne, MD; Jean Paul Soucy, MD; Eduardo R. Zimmer, PhD; Lucas P. Schilling, PhD; Thomas K. Karikari, PhD; Nicholas J. Ashton, PhD; Henrik Zetterberg, PhD; Kaj Blennow, PhD; Serge Gauthier, MD; Victor Valcour, PhD; Bruce L. Miller, MD; Pedro Rosa-Neto, PhD; Tharick A. Pascoal, PhD
JAMA Network
APOEε4 potentiates amyloid β effects on longitudinal tau pathology
João Pedro Ferrari-Souza, Bruna Bellaver, Pâmela C. L. Ferreira, Andréa L. Benedet, Guilherme Povala, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Carolina Soares, Yi-Ting Wang, Mira Chamoun, Stijn Servaes, Arthur C. Macedo, Marie Vermeiren, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, Ann Cohen, Oscar L. Lopez, William E. Klunk, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Gallen Triana-Baltzer, Ziad S. Saad, Hartmuth C. Kolb, Thomas K. Karikari, Victor L. Villemagne, Dana L. Tudorascu, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto & Tharick A. Pascoal
Nature Aging
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
Pamela C. L. Ferreira, Joseph Therriault, Cécile Tissot, João Pedro Ferrari-Souza, Andréa L. Benedet, Guilherme Povala, Bruna Bellaver, Douglas T. Leffa, Wagner S. Brum, Firoza Z. Lussier, Gleb Bezgin, Stijn Servaes, Marie Vermeiren, Arthur C. Macedo, Arlec Cabrera, Jenna Stevenson, Gallen Triana-Baltzer, Hartmuth Kolb, Nesrine Rahmouni, William E. Klunk, Oscar L. Lopez, Victor L. Villemagne, Ann Cohen, Dana L. Tudorascu, Eduardo R. Zimmer, Thomas K. Karikari, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto, Tharick A. Pascoal
Alzheimer’s & Dementia
The GABAergic system in Alzheimer’s disease: a systematic review with meta-analysis
Giovanna Carello-Collar, Bruna Bellaver, Pamela C L Ferreira, João Pedro Ferrari-Souza, Vanessa G Ramos, Joseph Therriault, Cécile Tissot, Marco A De Bastiani, Carolina Soares, Tharick A Pascoal, Pedro Rosa-Neto, Diogo O Souza, Eduardo R Zimmer
Mol Psychiatry. 2023
The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework
Arthur C Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R Zimmer, Marie-Christine Guiot, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Neto
J Nucl Med. 2023
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies
Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blennow
Nat Aging. 2023
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Andréa L. Benedet, Nicholas J. Ashton, Gallen Triana-Baltzer, Hartmuth C. Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L. Lopez, Dana L. Tudorascu, Victor L. Villemagne, Milos D. Ikonomovic, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Howard J. Aizenstein, William E. Klunk, Beth E. Snitz, Pauline Maki, Rebecca C. Thurston, Ann D. Cohen, Mary Ganguli, Thomas K. Karikari, Pedro Rosa-Neto & Tharick A. Pascoal
Nature Medicine (2023)
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
João Pedro Ferrari-Souza, Firoza Z. Lussier, Douglas T. Leffa, Joseph Therriault, Cécile Tissot, Bruna Bellaver, Pâmela C. L. Ferreira, Maura Malpetti, Yi-Ting Wang, Guilherme Povala, Andréa L. Benedet, Nicholas J. Ashton, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, JennaStevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, John T. O’Brien, James B. Rowe, Ann D. Cohen, Oscar L. Lopez, Dana L. Tudorascu, Thomas K. Karikari, William E. Klunk, Victor L. Villemagne, Jean-Paul Soucy, Serge Gauthier, Diogo O. Souza, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Pedro Rosa-Neto,Tharick A. Pascoal
Science Advances, 5 Apr 2023, Vol 9, Issue 14
DOI: 10.1126/sciadv.ade1474
Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology
Bruna Bellaver, Albert Puig-Pijoan, João Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cécile Tissot, Guilherme Povala, Joseph Therriault, Andréa L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suárez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal.
Alzheimer’s & Dementia 15 March 2023 https://doi.org/10.1002/alz.13014