Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease.
Terada T, Therriault J, Kang MS, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Poltronetti NM, Ottoy J, Arias JF, Bezgin G, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P.
Eur J Neurol. 2022 May;29(5):1324-1334. doi: 10.1111/ene.15246. Epub 2022 Jan 22.
Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease.
Cassidy CM, Therriault J, Pascoal TA, Cheung V, Savard M, Tuominen L, Chamoun M, McCall A, Celebi S, Lussier F, Massarweh G, Soucy JP, Weinshenker D, Tardif C, Ismail Z, Gauthier S, Rosa-Neto P.
Neuropsychopharmacology. 2022 Apr;47(5):1128-1136. doi: 10.1038/s41386-022-01293-6. Epub 2022 Feb 17.
A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer’s disease.
Brum WS, de Bastiani MA, Bieger A, Therriault J, Ferrari-Souza JP, Benedet AL, Saha-Chaudhuri P, Souza DO, Ashton NJ, Zetterberg H, Pascoal TA, Karikari T, Blennow K, Rosa-Neto P, Zimmer ER; Alzheimer’s Disease Neuroimaging Initiative (ADNI).
Alzheimers Dement (N Y). 2022 Mar 13;8(1):e12270. doi: 10.1002/trc2.12270. eCollection 2022.
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer’s disease.
Ashton NJ, Benedet AL, Pascoal TA, Karikari TK, Lantero-Rodriguez J, Brum WS, Mathotaarachchi S, Therriault J, Savard M, Chamoun M, Stoops E, Francois C, Vanmechelen E, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Rosa-Neto P.
EBioMedicine. 2022 Feb;76:103836. doi: 10.1016/j.ebiom.2022.103836. Epub 2022 Feb 12.
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET.
Tissot C, Therriault J, Kunach P, L Benedet A, Pascoal TA, Ashton NJ, Karikari TK, Servaes S, Lussier FZ, Chamoun M, Tudorascu DL, Stevenson J, Rahmouni N, Poltronetti NM, Pallen V, Bezgin G, Kang MS, Mathotaarachchi SS, Wang YT, Fernandez Arias J, Ferreira PCL, Ferrari-Souza JP, Vanmechelen E, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P.
EBioMedicine. 2022 Feb;76:103837. doi: 10.1016/j.ebiom.2022.103837. Epub 2022 Feb 6.
Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia.
Savard M, Pascoal TA, Servaes S, Dhollander T, Iturria-Medina Y, Kang MS, Vitali P, Therriault J, Mathotaarachchi S, Benedet AL, Gauthier S, Rosa-Neto P; Frontotemporal Lobar Degeneration Neuroimaging Initiative.
Elife. 2022 Jan 24;11:e73510. doi: 10.7554/eLife.73510.
Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects.
Gogola A, Minhas DS, Villemagne VL, Cohen AD, Mountz JM, Pascoal TA, Laymon CM, Mason NS, Ikonomovic MD, Mathis CA, Snitz BE, Lopez OL, Klunk WE, Lopresti BJ.
J Nucl Med. 2022 Jan;63(1):108-116. doi: 10.2967/jnumed.120.254961. Epub 2021 Apr 16.
Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.
Pascoal TA, Benedet AL, Tudorascu DL, Therriault J, Mathotaarachchi S, Savard M, Lussier FZ, Tissot C, Chamoun M, Kang MS, Stevenson J, Massarweh G, Guiot MC, Soucy JP, Gauthier S, Rosa-Neto P.
Brain. 2021 Dec 16;144(11):3517-3528. doi: 10.1093/brain/awab248.
Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology.
Povala G, Bellaver B, De Bastiani MA, Brum WS, Ferreira PCL, Bieger A, Pascoal TA, Benedet AL, Souza DO, Araujo RM, Zatt B, Rosa-Neto P, Zimmer ER; for the Alzheimer’s Disease Neuroimaging Initiative.
Cell Biosci. 2021 Dec 11;11(1):204. doi: 10.1186/s13578-021-00712-3.