A multicentre validation study of the diagnostic value of plasma neurofilament light.
Ashton NJ, Janelidze S, Al Khleifat A, Leuzy A, van der Ende EL, Karikari TK, Benedet AL, Pascoal TA, Lleó A, Parnetti L, Galimberti D, Bonanni L, Pilotto A, Padovani A, Lycke J, Novakova L, Axelsson M, Velayudhan L, Rabinovici GD, Miller B, Pariante C, Nikkheslat N, Resnick SM, Thambisetty M, Schöll M, Fernández-Eulate G, Gil-Bea FJ, López de Munain A, Al-Chalabi A, Rosa-Neto P, Strydom A, Svenningsson P, Stomrud E, Santillo A, Aarsland D, van Swieten JC, Palmqvist S, Zetterberg H, Blennow K, Hye A, Hansson O.
Nat Commun. 2021 Jun 7;12(1):3400. doi: 10.1038/s41467-021-23620-z.
Interactive rather than independent effect of APOE and sex potentiates tau deposition in women.
Wang YT, Pascoal TA, Therriault J, Kang MS, Benedet AL, Savard M, Tissot C, Lussier FZ, Arias JF, Mathotaarachchi S, Rajah MN, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.
Brain Commun. 2021 Jun 7;3(2):fcab126. doi: 10.1093/braincomms/fcab126. eCollection 2021.
What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.
Villemagne VL, Lopresti BJ, Doré V, Tudorascu D, Ikonomovic MD, Burnham S, Minhas D, Pascoal TA, Mason NS, Snitz B, Aizenstein H, Mathis CA, Lopez O, Rowe CC, Klunk WE, Cohen AD.
J Nucl Med. 2021 May 10;62(5):614-619. doi: 10.2967/jnumed.120.245423. Epub 2020 Dec 31.
Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology.
Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, Snellman A, Schöll M, Troakes C, Hye A, Gauthier S, Vanmechelen E, Zetterberg H, Rosa-Neto P, Blennow K.
Acta Neuropathol. 2021 May;141(5):709-724. doi: 10.1007/s00401-021-02275-6. Epub 2021 Feb 14.
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease.
Lyra E Silva NM, Gonçalves RA, Pascoal TA, Lima-Filho RAS, Resende EPF, Vieira ELM, Teixeira AL, de Souza LC, Peny JA, Fortuna JTS, Furigo IC, Hashiguchi D, Miya-Coreixas VS, Clarke JR, Abisambra JF, Longo BM, Donato J Jr, Fraser PE, Rosa-Neto P, Caramelli P, Ferreira ST, De Felice FG.
Transl Psychiatry. 2021 Apr 28;11(1):251. doi: 10.1038/s41398-021-01349-z.
Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease.
Terada T, Therriault J, Kang MSP, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P.
Mol Neurodegener. 2021 Apr 26;16(1):28. doi: 10.1186/s13024-021-00448-1.
Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals.
Lussier FZ, Benedet AL, Therriault J, Pascoal TA, Tissot C, Chamoun M, Mathotaarachchi S, Savard M, Ashton NJ, Karikari TK, Rodriguez JL, Snellman A, Bezgin G, Kang MS, Fernandez Arias J, Wang YT, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.
Brain Commun. 2021 Apr 15;3(2):fcab073. doi: 10.1093/braincomms/fcab073. eCollection 2021.
Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer’s disease.
Tissot C, Therriault J, Pascoal TA, Chamoun M, Lussier FZ, Savard M, Mathotaarachchi SS, L Benedet A, Thomas EM, Parsons M, Nasreddine Z, Rosa-Neto P, Gauthier S.
Alzheimers Dement (N Y). 2021 Mar 31;7(1):e12154. doi: 10.1002/trc2.12154. eCollection 2021.
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease.
Tissot C, L Benedet A, Therriault J, Pascoal TA, Lussier FZ, Saha-Chaudhuri P, Chamoun M, Savard M, Mathotaarachchi SS, Bezgin G, Wang YT, Fernandez Arias J, Rodriguez JL, Snellman A, Ashton NJ, Karikari TK, Blennow K, Zetterberg H, De Villers-Sidani E, Huot P, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.
Alzheimers Res Ther. 2021 Mar 29;13(1):69. doi: 10.1186/s13195-021-00802-x.